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A0A9P6D3H2 · A0A9P6D3H2_PLEER

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BDN71DRAFT_1498932

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 90797
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Pleurotineae > Pleurotaceae > Pleurotus

Accessions

  • Primary accession
    A0A9P6D3H2

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane70-88Helical
Transmembrane108-130Helical
Transmembrane137-156Helical
Transmembrane162-182Helical
Transmembrane194-219Helical
Transmembrane231-251Helical
Transmembrane307-327Helical
Transmembrane347-365Helical
Transmembrane377-394Helical
Transmembrane406-425Helical
Transmembrane592-614Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias525-552Polar residues
Region525-582Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    623
  • Mass (Da)
    68,266
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    559E480119382E38712C4CD4AC0D6CF5
MLEEPEQSYRRSSCDELLFQAEVDMDDQNSIASSQSSSNASVGDIVPQPVPRRTAADVAARKWRMYCIRLIALLCACSLSIGSHYASYVLGPLKSRLSRELGTSHTEFSLLISAFSLNSTWTPLVGGVMASRLGTTFTSILATGVILLGQILFLTGDIYGNVRMMALGMFVFGLGVSPLAVVQETIIVRFFKSHGLGVSMAFGLIAGKGASFISARTSYPLTERFGSRAPFYVATGLAALSVFVNLIYIAASRWLVDGAGAELEAADIDEEARRRSCHDISQAQALEKVAEKRRVHIKEITKLGDIFWSYVGLNVLCGAIWSPFTHLAANIVEKRYGMTEEDAANQASYLLAGSVVLYPICGYIVDRYKSKQIVIRLFMLSSILTGSCYLWLSLPPSWTRSSWPGILSFCIGHGFAPLLLVVLVPKIVALKYVSTALGVHKSLEQTGSTIFQTMAGLALDMHNTKPQDPNGPTPPSQKSSIQQLLNIFVILNGLQFLSILALSYLQQRQKRLLWHRSSISEGALSNSVSTVKPHDSGSNIEPQASGSDHSQERPLLGGSEVSHMRYSSTMSRRSGPTRDEVRQRGEIRRGRIFVTLSASLIIFAWVLFMGTAWFRLGSKHETN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias525-552Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU154664
EMBL· GenBank· DDBJ
KAF9489652.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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