A0A9P5ZK47 · A0A9P5ZK47_PLEER

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site71-76FMN (UniProtKB | ChEBI)
Binding site122-125FMN (UniProtKB | ChEBI)
Binding site164-173FMN (UniProtKB | ChEBI)
Binding site199FMN (UniProtKB | ChEBI)
Binding site288NADP+ (UniProtKB | ChEBI)
Binding site455-458FAD (UniProtKB | ChEBI)
Binding site473-475FAD (UniProtKB | ChEBI)
Binding site479FAD (UniProtKB | ChEBI)
Binding site494-497FAD (UniProtKB | ChEBI)
Binding site574NADP+ (UniProtKB | ChEBI)
Binding site645-646NADP+ (UniProtKB | ChEBI)
Binding site655-659NADP+ (UniProtKB | ChEBI)
Binding site731FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • ORF names
      BDN71DRAFT_1455922

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 90797
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Pleurotineae > Pleurotaceae > Pleurotus

Accessions

  • Primary accession
    A0A9P5ZK47

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Cell membrane
; Single-pass membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain65-215Flavodoxin-like
Domain268-543FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    732
  • Mass (Da)
    80,745
  • Last updated
    2023-09-13 v1
  • Checksum
    5BEE377727EBD9D5
MASTSSSDVLVLAVGVALAAIYLFRDQLFAQAKPKSVPVLTSKALNGSGNPRDFIAKMKEGKKRLVIFYGSQTGTAEEYAIRLAKEAKSKFGLASLVCDPEEYDFENLDQLPEDCAIFFVMATYGEGEPTDNAVTLMQNLEDESFEFSNGEHRLEGLKYVVFSLGNKTYEHYNKIGRDVDNVLTKMGAIRIGERGEGDDDKSMEEDYLEWKDGMWDAFSAAMGVEEGQGGDTPDFAVTELESHPTEKVYLGELSARALTKTKGIHDAKNPFPAPISVARELFQSTHDRNCVHIELNTESSGISYQHGDHVGVWPSNPDVEVTRLLCALGLYEKKDNVIGIESLDPALAKVPFPVPTTYATVLRHYIDISAVAGRQILGALSKFAPNPEAEAFLKGLSTNKEEYHSLIANGCLKLGEVLQLAAGNDLSAAPTPENTTAWTIPFDIIVSSIPRLQPRYYSISSSPKLHPNSIHVTAVVLKYESIPNKRVNGRWIFGVGSNFLLNLKYAANEETAPLVATGSEFKAASVTIPGYAIEGPRGAYKQETIYKAPIHVRRSTFRLPTNPKSPVIMIGPGTGVAPFRGFIQERVALARRSIEKNGSDALADWGRISLFYGCRKSTEDFLYKDEWAQYQEELRGKFTMHCAFSREVYRPDGSKIYVQDLLWDDREQVADAIINGKGYIYICGDAKSMSKSVEETLARILGEAKGGSAEVEGNAEVKLLKERSRLMLDVWS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU154667
EMBL· GenBank· DDBJ
KAF9489558.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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