Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

A0A9P5Z4K4 · A0A9P5Z4K4_9AGAR

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BDN70DRAFT_876378

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CIRM-BRFM 674
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Agaricales > Agaricineae > Strophariaceae > Pholiota

Accessions

  • Primary accession
    A0A9P5Z4K4

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane86-107Helical
Transmembrane128-150Helical
Transmembrane156-175Helical
Transmembrane187-211Helical
Transmembrane217-239Helical
Transmembrane251-271Helical
Transmembrane327-347Helical
Transmembrane368-387Helical
Transmembrane393-414Helical
Transmembrane495-519Helical
Transmembrane587-610Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias31-45Basic and acidic residues
Region31-64Disordered
Domain92-522Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    619
  • Mass (Da)
    68,333
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    01DC224B92A82B2A2DAFA7BE0B7270D0
MSADPPPNIGAQVLLKDTDDDDYLRAECDHLLQTSGRDSDSEHEQPAESGGLLGEESGEEDEDELLLHSRQTLSEAALKSRMRRAFFVRTLALLCACSLSVGSHYATNILGPLKSRLQREMGTSHTQFGLLLSAFSLNSTWTPLVGGILASRLGTTFTSILATGVILLGQIFLLCGDIWEDIRLMTLGLFIFGLGVSPLAVVQETIIVRFFKSHGLGVSMAFGLIAGKGASFVAARTSYPLTERFGPRAPFYVATSLASLSVIINLLYISLSKWLIDGAGAELEAPDINDEARRRVAINLTEAQALEKVAQKRKVHLRQITKLGDVFWAYMGLNLFCGMIWSPFDHLAANIIEHRYHMKEDDAANSAAYLLAGPIVLYPLCGFLVDYKKHRPIVIQLMLLSSSLTMFAYIWFALSPAWTKTPVPAIFSFAVGHGFSPLLLVVLVPKIVPSKYISTALGAHKSMEQTGSTLFQTLSGLLLDSKKPGEKPNETTFQYLLNTFVTLNVLQFGTILLLVLLQYHRLKRSHSRRSSFGGSEVRTSQIARRSEETPLLTGCHSQYLSSGTLDATIAEFRPDNHKRRSEIRRGVFMAVLCTTLVVSAWISFMLTAWYKLGQKRGEH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias31-45Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU155179
EMBL· GenBank· DDBJ
KAF9481407.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help