A0A9P5VXL7 · A0A9P5VXL7_9FUNG

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BGX34_008823

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NVP85
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mortierellomycotina > Mortierellomycetes > Mortierellales > Mortierellaceae > Mortierella

Accessions

  • Primary accession
    A0A9P5VXL7

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical
Transmembrane69-86Helical
Transmembrane106-125Helical
Transmembrane209-229Helical
Transmembrane249-268Helical
Transmembrane275-294Helical
Transmembrane300-321Helical
Transmembrane333-356Helical
Transmembrane368-387Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-392Major facilitator superfamily (MFS) profile
Region406-437Disordered
Compositional bias407-437Basic and acidic residues

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    540
  • Mass (Da)
    59,728
  • Last updated
    2023-09-13 v1
  • Checksum
    BBCF1E1C28B4724B
MGGVLIDHLSASKMLLVFSLFVCAGQGIFAIGVSTKSIWTMILGRLIFGIGGECLEVAQAKITTDWFKARWLGFALGLNLSFARIGTALNDNISPVIATGGGGVVAASWVGFAICGLSLAAGIWLSHLDGAESRRSAGVRLDVSYKRSDRIQSRTDNIIGRHALNASSDSTMSMSSVALEEEDEIEKDDEMAQDDRMLISEVFTLQPNFWVLSLCCITLYGAVVPFIHVSSDFLQKKWYANNPTKAGTVMSIPDIVSAIGSPLCGYLVDQFGYRARYIPLSALLLVWAHVQLGFTLVTPIMAMFILGLAYSLFASVLWPCIPFLVKDHQLGTAYGLVTIALNISLTIFPLVVASILEATQGSYTHVEGLFIALAFTGLLLSILFNVLDYRQGGYLQLTENPLDLYSSDDDDEGRTRRSQRGQRVRQDPNDPREPGFEYRRSRRYSRALLHEEDPDIEDVQVMVTTKPKERDEVSCYLNSIPFLRACLIYPHILAQEGHDSAHADQPTWRAVLEGKGHSHKLDLVERKRFLSVCLTSRRSF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias407-437Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAAVA010000508
EMBL· GenBank· DDBJ
KAF9358668.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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