A0A9P5VL55 · A0A9P5VL55_9FUNG

  • Protein
    Inosine triphosphate pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site34Mg2+ (UniProtKB | ChEBI)
Binding site46ITP (UniProtKB | ChEBI)
Binding site62Mg2+ (UniProtKB | ChEBI)
Binding site62-63ITP (UniProtKB | ChEBI)
Binding site138-141ITP (UniProtKB | ChEBI)
Binding site161ITP (UniProtKB | ChEBI)
Binding site166-167ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      BG006_006812

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NVP1
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mortierellomycotina > Mortierellomycetes > Mortierellales > Mortierellaceae > Podila

Accessions

  • Primary accession
    A0A9P5VL55

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    184
  • Mass (Da)
    20,348
  • Last updated
    2023-09-13 v1
  • Checksum
    38C4ECF1699D7C41
MALKKLGNKNKLVEVQQILGPHFDLQSVKIDLPELQGTTQDVSKEKCRQAAEIVKGPVITEDTSLGFNALNGLPGPYIKWFLEGVGHTGLNKMLDGFEDRSAFALCTFALSKGPGTEPILFEGRTDGSIVQARGPTHFGWDPVFLPDGFDTTYAEMDKDIKNTISHRGRALAKLREYLEKEENN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAAUY010000413
EMBL· GenBank· DDBJ
KAF9330222.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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