A0A9P5HID2 · A0A9P5HID2_9HYPO
- ProteinLysosomal dipeptide transporter MFSD1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids527 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.
Catalytic activity
- L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
- L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
- L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
- L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
- L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
- L-arginyl-glycine(out) = L-arginyl-glycine(in)
- L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
- L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
- L-histidyl-glycine(out) = L-histidyl-glycine(in)
- L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
- L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
- L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
- L-lysyl-glycine(out) = L-lysyl-glycine(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | transmembrane transporter activity |
Names & Taxonomy
Protein names
- Recommended nameLysosomal dipeptide transporter MFSD1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Cylindrodendrum
Accessions
- Primary accessionA0A9P5HID2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 215-237 | Helical | |||
Transmembrane | 272-294 | Helical | |||
Transmembrane | 314-334 | Helical | |||
Transmembrane | 341-362 | Helical | |||
Transmembrane | 368-386 | Helical | |||
Transmembrane | 398-417 | Helical | |||
Transmembrane | 437-461 | Helical | |||
Transmembrane | 498-519 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.
Structure
Sequence
- Sequence statusComplete
- Length527
- Mass (Da)57,383
- Last updated2023-09-13 v1
- ChecksumB45F120F3CB7B967
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAANBB010000019 EMBL· GenBank· DDBJ | KAF7555544.1 EMBL· GenBank· DDBJ | Genomic DNA |