A0A9P5HID2 · A0A9P5HID2_9HYPO

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      G7Z17_g2085

Organism names

  • Taxonomic identifier
  • Strain
    • IHI 201604
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Cylindrodendrum

Accessions

  • Primary accession
    A0A9P5HID2

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane215-237Helical
Transmembrane272-294Helical
Transmembrane314-334Helical
Transmembrane341-362Helical
Transmembrane368-386Helical
Transmembrane398-417Helical
Transmembrane437-461Helical
Transmembrane498-519Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-24Disordered
Domain56-461Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    57,383
  • Last updated
    2023-09-13 v1
  • Checksum
    B45F120F3CB7B967
MAQLQGDVAEQGTPEQRLELGNKEAHLITEVKPSSTSSDSGRDGLKPVPLTWKLASVVLVTAIGFGSQWSSGITGAMKSTIKKEMNINNTQFSLLEASEDFMVTALMLLSGIVTDRIGGAGAMLYGNVIYSVGSILVAAAAQTRSYKFMIAGRVIRALGDIATQVAQYKVFSSWFAPGNGFASTLGFELGIGKIGAFAGKSSANIIAKNTGDFAWVFWVAVFMNIFTNVMTGVFYWFTKVANSKFHGVDDPATGERLTEKTKKFELRKILELPWSFWCVMLFSLFETSTAIVFLQNATELAEQRFGTDSIAAGWYSSVLQYAGFFVVPLLGVFLDMYGQRISILVFCGIGMFTSMLLVTFSAGTTGTAASFGVFAFAYCFGPTTIIDGTRTSMWDSTVFGSAYSIKIMLNNAMNIIVRVITGRIQDADNNSYDKVTIVYTILAGCSVAVSLLLAVIAWRSVDLGHLQWTRKMRIARGAILNERKARFYEEKGGRNKTISMVCFASLIALTLGSWCAYFWGVATGNNE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAANBB010000019
EMBL· GenBank· DDBJ
KAF7555544.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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