A0A9P4XFP5 · A0A9P4XFP5_9HYPO

Function

function

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal tripeptide from a polypeptide.
    EC:3.4.14.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

115742004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site275Charge relay system
Active site279Charge relay system
Active site496Charge relay system
Binding site539Ca2+ (UniProtKB | ChEBI)
Binding site540Ca2+ (UniProtKB | ChEBI)
Binding site564Ca2+ (UniProtKB | ChEBI)
Binding site566Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular Functionserine-type endopeptidase activity
Molecular Functiontransferase activity
Molecular Functiontripeptidyl-peptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tripeptidyl-peptidase II
  • EC number

Gene names

    • ORF names
      CFAM422_006975

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CFAM-422
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Hypocreaceae > Trichoderma

Accessions

  • Primary accession
    A0A9P4XFP5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_504035725321-1574tripeptidyl-peptidase II

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain196-586Peptidase S53
Domain593-1199Deacetylase sirtuin-type
Region647-773Disordered
Compositional bias655-705Basic and acidic residues
Compositional bias712-735Polar residues
Compositional bias741-755Pro residues
Region808-850Disordered
Compositional bias969-1013Polar residues
Region969-1026Disordered
Region1197-1236Disordered
Compositional bias1199-1229Basic and acidic residues
Region1287-1380Disordered
Compositional bias1350-1366Basic and acidic residues

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,574
  • Mass (Da)
    170,576
  • Last updated
    2023-09-13 v1
  • Checksum
    C667035ECFC1B4A6
MKSALLWAVQLSLLAGLGASRRNVEQVLSIPTGWTKFQDVVNPARHMRLSIALRQPNIDQLETKMTENDNRLSLEEIQQLQAPDQKDVDAVLQWLSQNNLKGEVDNNFIHVTTTVAQAEPLLGMKVSRFAYKDKKPVLRTTKYTVPDSVAGSISFIHPLANFMTARHKPEVVSAPPKPASKAAAADEDNIIYCPGSVTPSCLAQLYNISSYKPADNKSPVIFGVAGFLEENANLLDLQQFLNSAAPNVAQAGKSITVELVNGGVNSQDLAESGHEAALDVDYAVSVGFPTNVTYYATGGRGVKLDDNGQPISGEDDDNEPYLEFFRYLLAKPDHQVPHVLSLSYSDDELSVPREYAKHVCSLFGLLTARGTSIIFSSGDGGARGGRDSSCLTNDGTKRPVAMATFPPTCPWVTSVGAVTNGAEPPSGASFSTGGFSQYFARPHWQDSSVKNYVQALNGRLDGLYDPSMRAIPDISAVGTSFMIIASGIPHFLQGTSASAPVFASMVALINDARLRAGKRSLGWLNQHLYSNKVKNVLQDITVGKSLSCVFNNTEVPGGWPAAPGWDAITGLGVPKEFDKFLQVLYDMPTQHVEPETHGLLQEVANSLLKARKVVVVTGAGISTNSGIPDFRSENGLYSLIQAQFDAASQPTRSTDRFKTDGDGNGNGDGGEEPRPTKRRKVSREPSPDLDEVDRQLNEDIKARAEAEMPAASSQAADTQQAVAASDPNASENGCLSTPRPKPALPSTPKPTTTSPLSSPPREEFMLPLPLASSSLRAEDRERIAGVSQNIVSSPLSSPPPVLFDPFHPSSPSDENMSRRSSTTPSEVDEMRDLPNAMPASQASNPGKTTLPNMKGKDLFDASIWSDPTRTSVFYQFATSLRQKVREAEPTSSHKFIGHLRDRGKLVRCYTQNIDQIEEKVGLSTSLLAGPGSRGRFSRKSTANAAQLNKMVEEVSSSGEGGNAGDVGDVGASSQSPTNGSSEQTPADQRQTSSQPNGKTEEDETTTSSTTTPPNQQPKPAPRKEVPPLRSGVECVFLHGSLQLLRCFLCGQVCSWDDDDREVETLSGQQPECPHCVGATEARQERGKRALGVGKLRPDIVLYGEEHPNAHLISPIVTHDLALYPDMLLILGTSLRVHGLKVMVREFAKTVHSKGGKVVFVNFTKPPESSWGDIIDYWIQWDCDAWVADLQVRIPKLWQEPEPPKPKKKRDSGGGAAEEGREEKKKPPAQNPVALRDTKVNGAYCTLKILKELRRITATSPPLPIILSLPPSLSTAPPLLERVSAAVTTEAKPNPDPPTPAEVAPRAAAVMDPPTRISTPRGKAKRPRKSAPGALERPKRTPSTLNPNHGRSKKPVEEVKEEEVLETPETPSQPPVSTVEEFSSILHSVKSNPRIRKRKMIDGEEFVFPTIGKKRGAVDSLYKGAEDDKKQLPPLRPVPDQATGVASLPAEAEAEDAIEEPLASISVNVRAATTFTRPEAFYIQDPLVTLLEKAPQWKAMEVNHGELRRNKRRISKRFLPVQVQMETKAQAEANAALALAGLRTNSHMVPQVAHAVPGNGYTELANWAATWSCKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias655-705Basic and acidic residues
Compositional bias712-735Polar residues
Compositional bias741-755Pro residues
Compositional bias969-1013Polar residues
Compositional bias1199-1229Basic and acidic residues
Compositional bias1350-1366Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QLNT01000011
EMBL· GenBank· DDBJ
KAF3070031.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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