A0A9P2G965 · A0A9P2G965_CLOBO

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site120ATP (UniProtKB | ChEBI)
Binding site204ATP (UniProtKB | ChEBI)
Binding site239ATP (UniProtKB | ChEBI)
Active site296
Binding site538Mn2+ (UniProtKB | ChEBI)
Binding site610substrate
Binding site707Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site736Mn2+ (UniProtKB | ChEBI)
Binding site738Mn2+ (UniProtKB | ChEBI)
Binding site871substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • Name
      pyc
    • ORF names
      CLG_B0193

Organism names

Accessions

  • Primary accession
    A0A9P2G965

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue707N6-carboxylysine
Modified residue1111N6-biotinyllysine

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-457Biotin carboxylation
Domain124-321ATP-grasp
Domain529-797Pyruvate carboxyltransferase
Domain1067-1145Lipoyl-binding

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,145
  • Mass (Da)
    127,711
  • Last updated
    2023-09-13 v1
  • Checksum
    BE159589D735DB54
MTRKFKRVLVANRGEIAIRIFRACNELGIRTVAIYSEEDKFSLFRTKADEAYLIGKNQGPIEAYLNIDEIISLALKKGVDAIHPGYGFLSENAEFARKCEEAGIEFIGPTAEMMEKLGDKIKSKLVAQSVGVPTIPGVEKPVTSEEEAIKFADFCGYPIMLKAAAGGGGRGMRIVRNKEELLPSFRSAKNEAKKAFGIDDIFIEKYLENPKHIEVQVIGDKHGNIVHLYERDCSIQRRHQKVIEFTPAFALPEEKREKICNDALKIAKSVNYRSAGTLEFLVDIHGNHYFIEMNPRVQVEHTITEMTTGIDIVQSQILVAMGKPLSCAEIGIKHQQDVKPRGFAIQCRITTEDPTNNFAPDTGKIDVYRTGSGFGVRLDGGNGFTGAVISPYYDSLLVKTTTWARSFEDAIRKSLRSMKELTISGVKTNVGFLINVLNHPTFAEGKCTTKFIEENSELFKIFTKTDREYNLLKYIGEKVVNETFGVKKEFDVPLVPKVIVPNDLRGTKQILDEKGPNGLVDWIKSQEKLLITDTTMRDAHQSLMATRMRSIDMIKVAKSTSVLEKDAFSLEMWGGATFDVAYRFLKESPWIRLQELRKRIPNILFQMLIRGSNGVGYKNYPDNVIRKLIDESANSGIDVFRIFDSLNWVKGMEVAIDQVLKNNKIAEACICYTGDILDNRKDKYSLDYYVKKAKEIEKTGAHILGIKDMSALLKPYAAFKLIKALKEEVSMPIHLHTHDTTGNGVATVMMAAEAGVDIVDTAISSMAGLTSQPALNSVVAALENTKRATGMKAHDLQKISDYWAAVRPVYEQFESELKSGSTEIYRYEIPGGQYSNLKPQVESFGLGHRFNEVKEMYKKVNNMVGDIVKVTPSSKMVGDLAIFMVKNNLTPENIMEKGKDLAFPDSVVAYFKGMMGQPDGGFPKDLQKIVLKGEPPITCRPGELLPSEDFDAIKAYLSEKFNMEANNRNALSYTLYPDVYEEYLKSIQSDRDLSKMGSDIFFHGLREGETCEVEINEGQTMIIKLLEISKVDTNGNRSLYFEVNGNRREISVKDTSSLSAKNTEIVTTQMADTNNPLEVGSSIPGTVLKVLVNEGDEVKENDSLLVIEAMKMETNITASASGVVSSILVKEGQQVKSGELLVKLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACSJ01000001
EMBL· GenBank· DDBJ
EES92300.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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