A0A9N8V8V4 · A0A9N8V8V4_9GLOM

  • Protein
    Folylpolyglutamate synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a monovalent cation (UniProtKB | Rhea| CHEBI:60242 )

Note: A monovalent cation.

Pathway

Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site98Mg2+ 1 (UniProtKB | ChEBI)
Binding site172Mg2+ 1 (UniProtKB | ChEBI)
Binding site200Mg2+ 1 (UniProtKB | ChEBI)
Binding site314ATP (UniProtKB | ChEBI)
Binding site331ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processone-carbon metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      AGERDE_LOCUS894

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MT106
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Archaeosporales > Ambisporaceae > Ambispora

Accessions

  • Primary accession
    A0A9N8V8V4

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    522
  • Mass (Da)
    59,097
  • Last updated
    2023-09-13 v1
  • Checksum
    99AE5F74EAA6714A
MQSKRTYKNAIECLNTLQSRASILNALEKTGPLNFSDGLSLSINNFHTIGYEPKDYDKLNVIHVAGTKGKGSTCAFVESIIRNYPLKNKRIRTGLYTSPHLVSVRERIRMDGKQISEEKFTKYFFDCWDKFYNTTTTVNDHMDDNFPNYYRLVTLVAFHAFVEEQVDVVILEVGIGGEYDTTNVVKSPIVCGITSLGYDHQLLLGETINEIAWHKAGIFKKKVPALTVEQPKKAYEVLKQRAAEKEVIYSIDSKNSFHIRLNGRHQKINAALAIELCRVWFQTCHSNLNIGGLSSDKVPQEFLIGLEKTRLSGRGQIIKIPTMDQLTFYCDGAHTVESIQCCMDWFRETAFQDYSSKIPMYFKNYYVPQSRDNANQENSAAPTNVKRILLFNCTGKRSGLDLLKVITASPYIQFDYAVFCANVVYSDNHSEPDSKGPALSTISLTNQESFKNDWLSLIAQQETNNNILEQRAHLFPSIEHAINWIKEYVVRGTENNTHVQVLVSGSLHLVGGVLEVLGVDVE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJVPL010000052
EMBL· GenBank· DDBJ
CAG8438844.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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