A0A9N8V8V4 · A0A9N8V8V4_9GLOM
- ProteinFolylpolyglutamate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids522 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H+
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n) RHEA-COMP:14738 + CHEBI:29985 + CHEBI:30616 = (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n+1) RHEA-COMP:14740 + CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Cofactor
Note: A monovalent cation.
Pathway
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | tetrahydrofolylpolyglutamate synthase activity | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFolylpolyglutamate synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Archaeosporales > Ambisporaceae > Ambispora
Accessions
- Primary accessionA0A9N8V8V4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length522
- Mass (Da)59,097
- Last updated2023-09-13 v1
- Checksum99AE5F74EAA6714A
Keywords
- Technical term