A0A9N8UY81 · A0A9N8UY81_9GLOM

  • Protein
    Crossover junction endonuclease MUS81
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentHolliday junction resolvase complex
Cellular Componentnucleus
Molecular Function3'-flap endonuclease activity
Molecular Functioncrossover junction DNA endonuclease activity
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological ProcessDNA catabolic process
Biological Processdouble-strand break repair via break-induced replication
Biological Processmitotic intra-S DNA damage checkpoint signaling
Biological Processresolution of meiotic recombination intermediates

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Crossover junction endonuclease MUS81
  • EC number

Gene names

    • ORF names
      AGERDE_LOCUS547

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MT106
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Archaeosporales > Ambisporaceae > Ambispora

Accessions

  • Primary accession
    A0A9N8UY81

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Interacts with EME1.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region88-126Disordered
Region133-152Disordered
Region286-306Disordered
Domain324-419ERCC4

Sequence similarities

Belongs to the XPF family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    602
  • Mass (Da)
    69,007
  • Last updated
    2023-09-13 v1
  • Checksum
    5AA7E83C4F1FBB11
MPPRKQETPAPTCGNPLYKQWLEEMMEEAKAKNTNTYHTYKKACDSISKYPLGFTHPSEASILKGIGPGICAKLEKKLEEYCKQNRLPIPKKPAASPNANSKSKKRIIDHNNDTSEVIPNDSSKPKEEIIIDQSADAPEINEPPLKKQKKKPTYIPKYRSGSYAILLGLYLAHTKNPNSNGITKPELIKIAQQFCDSSFDMPQNPKHHYTAWGCMKTLQEKDLVYKDGCPHRFTLSEAGLEIAHQIVKTTNCVFIDLDVNAIQNVTSKNMPTNDIDNDMTNPITVTTNSDKKLSESSGCSSSASRSAFPPFTPVEWLPGTFEVILLIDNREKRMQQDRDYFQQQLQQRDINTQTRSLELGDMIWIARRNLEETVLGYIMERKRMDDLVMSIKDGRFKEQKFRLSKAGAKQVIYLIEDYNMEEAEKYGMQAIETAMSETQVINGFFLKRTKNIEQTVDYLAALTRRFKSKYESQSLFIIPNNVIFRNTFLDLKRYLAKLHPERSYHISYEMYSEINSKRASLTVRDTFVKMLMTIKGVSAEKALEIVKKYPTPFQFVKALECLLDENDQKKMLSDATSFEIGRKKIQPVLSGKIAHIWCADEY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJVPL010000027
EMBL· GenBank· DDBJ
CAG8435529.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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