A0A9L9PYL0 · A0A9L9PYL0_HUMAN

  • Protein
    Mitochondrial fission factor
  • Gene
    MFF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial outer membrane
Cellular Componentperoxisome
Cellular Componentsynaptic vesicle
Biological Processmitochondrial fission
Biological Processpositive regulation of mitochondrial fission
Biological Processpositive regulation of protein targeting to membrane

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial fission factor

Gene names

    • Name
      MFF

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A9L9PYL0

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type IV membrane protein
Mitochondrion outer membrane
; Single-pass type IV membrane protein
Peroxisome

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane282-300Helical

Keywords

Disease & Variants

Variants

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The viewer provides 307 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)48PRIDEPhosphoserine
Modified residue (large scale data)67PRIDEPhosphoserine
Modified residue (large scale data)69PRIDEPhosphoserine
Modified residue (large scale data)79PRIDEPhosphoserine
Modified residue (large scale data)80PRIDEPhosphothreonine
Modified residue (large scale data)89PRIDEPhosphothreonine
Modified residue (large scale data)97PRIDEPhosphoserine
Modified residue (large scale data)111PRIDEPhosphothreonine
Modified residue (large scale data)112PRIDEPhosphothreonine
Modified residue (large scale data)129PRIDEPhosphoserine
Modified residue (large scale data)131PRIDEPhosphoserine
Modified residue (large scale data)146PRIDEPhosphoserine
Modified residue (large scale data)149PRIDEPhosphothreonine
Modified residue (large scale data)151PRIDEPhosphoserine
Modified residue (large scale data)171PRIDEPhosphoserine
Modified residue (large scale data)178PRIDEPhosphoserine
Modified residue (large scale data)182PRIDEPhosphoserine
Modified residue (large scale data)218PRIDEPhosphoserine
Modified residue (large scale data)223PRIDEPhosphoserine

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain1-302Mff-like
Region125-154Disordered
Compositional bias133-153Polar residues
Coiled coil253-280

Sequence similarities

Belongs to the Tango11 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    302
  • Mass (Da)
    34,345
  • Last updated
    2023-09-13 v1
  • Checksum
    A3199507E8F58B2E
MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVPNASVIMQVPERIVVAGNNEDVSFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPPTTPQNEEIRAVGRLKRERSMSENAVRQNGQLVRNDSLVTPSPQQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRSVRRQNEIRCERPVLRGGSAAATSNPHHDNVRYGISNIDTTIEGTSDDLTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR

Computationally mapped potential isoform sequences

There are 16 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9GZY8MFF_HUMANMFF342
C9J846C9J846_HUMANMFF34
C9JU19C9JU19_HUMANMFF86
C9JHF5C9JHF5_HUMANMFF138
C9JI76C9JI76_HUMANMFF32
C9JAF1C9JAF1_HUMANMFF71
A0A0A0MS29A0A0A0MS29_HUMANMFF221
A0A9L9PY92A0A9L9PY92_HUMANMFF316
A0A9L9PXN3A0A9L9PXN3_HUMANMFF300
H7C433H7C433_HUMANMFF271
E9PPW6E9PPW6_HUMANMFF89
E9PPR7E9PPR7_HUMANMFF52
E9PQX8E9PQX8_HUMANMFF69
E9PKS0E9PKS0_HUMANMFF71
E9PK16E9PK16_HUMANMFF59
A0A9H3ZVE5A0A9H3ZVE5_HUMANMFF264

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias133-153Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC097662
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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