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A0A9L9PXH6 · A0A9L9PXH6_HUMAN

  • Protein
    Nucleobindin-1
  • Gene
    NUCB1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular ComponentGolgi apparatus
Cellular Componentmembrane
Molecular Functioncalcium ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleobindin-1

Gene names

    • Name
      NUCB1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A9L9PXH6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Golgi apparatus, cis-Golgi network membrane
; Peripheral membrane protein
Secreted

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 505 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
Signal1-26UniProt
ChainPRO_504028869927-471UniProtNucleobindin-1
Modified residue (large scale data)96PRIDEPhosphoserine
Modified residue (large scale data)158PRIDEPhosphothreonine
Modified residue (large scale data)189PRIDEPhosphotyrosine
Modified residue (large scale data)234PRIDEPhosphoserine
Modified residue (large scale data)330PRIDEPhosphoserine
Modified residue (large scale data)379PRIDEPhosphoserine

Keywords

Proteomic databases

Interaction

Subunit

Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 with higher affinity for GNAI1 and GNAI3 than for GNAI2. Preferentially interacts with inactive rather than active GNAI3. Interaction with GNAI3 is inhibited when NUCB1 binds calcium, probably due to a conformational change which renders the GBA motif inaccessible.

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias203-229Basic and acidic residues
Region203-231Disordered
Domain250-285EF-hand
Region378-471Disordered
Compositional bias390-404Basic and acidic residues
Compositional bias405-420Polar residues
Compositional bias449-471Basic and acidic residues

Sequence similarities

Belongs to the nucleobindin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    471
  • Mass (Da)
    54,819
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    7C528632DA81191FCA516B3C8EF8E9E9
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPVSGPALLSSQDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL

Computationally mapped potential isoform sequences

There are 17 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q02818NUCB1_HUMANNUCB1461
C9J3C1C9J3C1_HUMANNUCB1124
F8WB20F8WB20_HUMANNUCB175
C9JKZ2C9JKZ2_HUMANNUCB1470
C9JBD3C9JBD3_HUMANNUCB1110
A0A9L9PYA9A0A9L9PYA9_HUMANNUCB1324
A0A9L9PYB2A0A9L9PYB2_HUMANNUCB1447
A0A9L9PYB5A0A9L9PYB5_HUMANNUCB1425
A0A9L9PXW3A0A9L9PXW3_HUMANNUCB1245
A0A9L9PXW6A0A9L9PXW6_HUMANNUCB1449
A0A9L9PXT8A0A9L9PXT8_HUMANNUCB1367
A0A9L9PXU2A0A9L9PXU2_HUMANNUCB1246
A0A9L9PXH3A0A9L9PXH3_HUMANNUCB1269
A0A9L9PXG8A0A9L9PXG8_HUMANNUCB1455
A0A9L9PXA1A0A9L9PXA1_HUMANNUCB1401
A0A9L9PX96A0A9L9PX96_HUMANNUCB1262
H7BZI1H7BZI1_HUMANNUCB1431

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias203-229Basic and acidic residues
Compositional bias390-404Basic and acidic residues
Compositional bias405-420Polar residues
Compositional bias449-471Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC026803
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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