A0A9L0RTE5 · A0A9L0RTE5_HORSE

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site45-50ATP (UniProtKB | ChEBI)
Binding site71a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site93-95a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site125-128a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site132CMP (UniProtKB | ChEBI)
Binding site166ATP (UniProtKB | ChEBI)
Binding site172a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site183a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site211ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP/dUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processphosphorylation
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Nucleoside-diphosphate kinase
      (EC:2.7.4.6
      ) . EC:2.7.4.6 (UniProtKB | ENZYME | Rhea)
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • Name
      CMPK1
    • Synonyms
      CMPK

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A9L0RTE5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Predominantly nuclear.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane216-236Helical

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region65-95NMPbind
Region165-175LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    242
  • Mass (Da)
    27,520
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    5241E1C83C0340421498F4F8D22300F8
MRSLCARRLLHVLGLRFPLPTRRPLFLCPRRLMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKDGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNEDNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKSVDEVCFPLMGVVMGVVTVIVMLIVDLRFGW

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7D3E3F7D3E3_HORSECMPK1228
A0A9L0R7F8A0A9L0R7F8_HORSECMPK1225
A0A5F5PYT1A0A5F5PYT1_HORSECMPK1179

Keywords

Genome annotation databases

Similar Proteins

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