A0A9L0RET5 · A0A9L0RET5_HORSE
- ProteinPlatelet-derived growth factor receptor alpha
- GenePDGFRA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1107 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Activity regulation
Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 590 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 617-625 | ATP (UniProtKB | ChEBI) | |||
Binding site | 618-625 | ATP (UniProtKB | ChEBI) | |||
Binding site | 645 | ATP (UniProtKB | ChEBI) | |||
Binding site | 693-699 | ATP (UniProtKB | ChEBI) | |||
Active site | 836 | Proton acceptor | |||
Binding site | 840 | ATP (UniProtKB | ChEBI) | |||
Binding site | 841 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 854 | Mg2+ (UniProtKB | ChEBI) | |||
Site | 980 | Important for interaction with phosphotyrosine-binding proteins | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | platelet-derived growth factor alpha-receptor activity | |
Biological Process | chemotaxis | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlatelet-derived growth factor receptor alpha
- EC number
- Short namesPDGF-R-alpha ; PDGFR-alpha
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionA0A9L0RET5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 543-567 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 67↔118 | ||||
Disulfide bond | 168↔207 | ||||
Disulfide bond | 253↔308 | ||||
Disulfide bond | 453↔519 | ||||
Keywords
- PTM
Interaction
Subunit
Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 46-131 | Ig-like | |||
Domain | 220-324 | Ig-like | |||
Domain | 611-972 | Protein kinase | |||
Region | 1036-1107 | Disordered | |||
Compositional bias | 1047-1062 | Basic and acidic residues | |||
Compositional bias | 1063-1078 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,107
- Mass (Da)125,005
- Last updated2023-09-13 v1
- MD5 ChecksumEEDDDEC494B8FD3DDA8F23D0BD0FAC42
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F7A2X2 | F7A2X2_HORSE | PDGFRA | 1109 | ||
A0A9L0TUL6 | A0A9L0TUL6_HORSE | PDGFRA | 1043 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1047-1062 | Basic and acidic residues | |||
Compositional bias | 1063-1078 | Polar residues | |||
Keywords
- Technical term