A0A9L0RET5 · A0A9L0RET5_HORSE

  • Protein
    Platelet-derived growth factor receptor alpha
  • Gene
    PDGFRA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

Catalytic activity

Activity regulation

Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.

Features

Showing features for binding site, active site, site.

111071002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site590Mg2+ (UniProtKB | ChEBI)
Binding site617-625ATP (UniProtKB | ChEBI)
Binding site618-625ATP (UniProtKB | ChEBI)
Binding site645ATP (UniProtKB | ChEBI)
Binding site693-699ATP (UniProtKB | ChEBI)
Active site836Proton acceptor
Binding site840ATP (UniProtKB | ChEBI)
Binding site841Mg2+ (UniProtKB | ChEBI)
Binding site854Mg2+ (UniProtKB | ChEBI)
Site980Important for interaction with phosphotyrosine-binding proteins

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionplatelet-derived growth factor alpha-receptor activity
Biological Processchemotaxis
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-derived growth factor receptor alpha
  • EC number
  • Short names
    PDGF-R-alpha
    ; PDGFR-alpha
  • Alternative names
    • Alpha platelet-derived growth factor receptor
    • Alpha-type platelet-derived growth factor receptor

Gene names

    • Name
      PDGFRA

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A9L0RET5

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane543-567Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond67↔118
Disulfide bond168↔207
Disulfide bond253↔308
Disulfide bond453↔519

Keywords

Interaction

Subunit

Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain46-131Ig-like
Domain220-324Ig-like
Domain611-972Protein kinase
Region1036-1107Disordered
Compositional bias1047-1062Basic and acidic residues
Compositional bias1063-1078Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,107
  • Mass (Da)
    125,005
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    EEDDDEC494B8FD3DDA8F23D0BD0FAC42
MSKALIHHIRLFLRFSRTMGTCHRALLVLGCLLTGPSLSFCQLSLPSILPNEDEKVVQLNSSFSLRCFGESEVSWQYPMSEEENPNVEIRNEENNSGLFVTVLEVVSASAAHTGLYTCYYNHTQTEESEIEGRRIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLLSSDGVVLASYDSRQGFNGTFSVGPYICEATVKGKKFRTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLSVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPNFSRLEAVDLHEVKHFVVDVQAYPPPRISWLKDNLTLIENLTEITTDIEKIQEIRYRSKLKLIRAKEEDSGHYTIVVQNEDDVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNISNIITEVHPRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEKPKKELDIFGLTPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKAMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7A2X2F7A2X2_HORSEPDGFRA1109
A0A9L0TUL6A0A9L0TUL6_HORSEPDGFRA1043

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1047-1062Basic and acidic residues
Compositional bias1063-1078Polar residues

Keywords

Genome annotation databases

Similar Proteins

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