A0A9L0R0P0 · A0A9L0R0P0_HORSE
- ProteinChloride intracellular channel protein
- GeneCLIC4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids236 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3.
Catalytic activity
- bromide(in) = bromide(out)
- chloride(in) = chloride(out)
- choline(out) = choline(in)
- fluoride(in) = fluoride(out)
- iodide(out) = iodide(in)
- nitrate(in) = nitrate(out)
- thiocyanate(in) = thiocyanate(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | anchoring junction | |
Cellular Component | centrosome | |
Cellular Component | chloride channel complex | |
Cellular Component | cytoplasmic vesicle membrane | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | chloride channel activity | |
Molecular Function | oxidoreductase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameChloride intracellular channel protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionA0A9L0R0P0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Cytoplasmic vesicle membrane ; Single-pass membrane protein
Membrane ; Single-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 64-227 | GST C-terminal | |||
Domain
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
Sequence similarities
Belongs to the chloride channel CLIC family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length236
- Mass (Da)26,809
- Last updated2023-09-13 v1
- MD5 Checksum164D43067E3C4D3BFB0C04D2F02E9EAC
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q2H514 | A0A3Q2H514_HORSE | CLIC4 | 278 | ||
F6QHY8 | F6QHY8_HORSE | CLIC4 | 253 | ||
A0A3Q2I537 | A0A3Q2I537_HORSE | CLIC4 | 235 | ||
A0A3Q2HEX5 | A0A3Q2HEX5_HORSE | CLIC4 | 264 |
Keywords
- Technical term