A0A9L0R0P0 · A0A9L0R0P0_HORSE

  • Protein
    Chloride intracellular channel protein
  • Gene
    CLIC4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentanchoring junction
Cellular Componentcentrosome
Cellular Componentchloride channel complex
Cellular Componentcytoplasmic vesicle membrane
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionchloride channel activity
Molecular Functionoxidoreductase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Chloride intracellular channel protein

Gene names

    • Name
      CLIC4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A9L0R0P0

Proteomes

Organism-specific databases

Subcellular Location

Cell junction
Cell membrane
; Single-pass membrane protein
Cytoplasmic vesicle membrane
; Single-pass membrane protein
Membrane
; Single-pass membrane protein
Cytoplasm
Mitochondrion
Nucleus

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain64-227GST C-terminal

Domain

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

Sequence similarities

Belongs to the chloride channel CLIC family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    236
  • Mass (Da)
    26,809
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    164D43067E3C4D3BFB0C04D2F02E9EAC
MFLSDSQAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNNEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q2H514A0A3Q2H514_HORSECLIC4278
F6QHY8F6QHY8_HORSECLIC4253
A0A3Q2I537A0A3Q2I537_HORSECLIC4235
A0A3Q2HEX5A0A3Q2HEX5_HORSECLIC4264

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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