A0A9K3CRJ1 · A0A9K3CRJ1_9EUKA
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids468 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = CO2 + D-ribulose 5-phosphate + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-14 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GLAVMG | ||||||
Binding site | 32-34 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: NRT | ||||||
Binding site | 73-75 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: VQA | ||||||
Binding site | 101 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 101 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: N | ||||||
Binding site | 127-129 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: SGG | ||||||
Active site | 182 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 185-186 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: HN | ||||||
Active site | 189 | Proton donor | ||||
Sequence: E | ||||||
Binding site | 190 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: Y | ||||||
Binding site | 259 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: K | ||||||
Binding site | 286 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: R | ||||||
Binding site | 444 | substrate; ligand shared between dimeric partners | ||||
Sequence: R | ||||||
Binding site | 450 | substrate; ligand shared between dimeric partners | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate catabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metamonada > Carpediemonas-like organisms > Kipferlia
Accessions
- Primary accessionA0A9K3CRJ1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 178-466 | 6-phosphogluconate dehydrogenase C-terminal | ||||
Sequence: GNAVKTVHNGCEYGVMQLIAETYHSIRRILGISTNEIGHIFESWQNTELSSYLVEITAIVLGHSDEDGEPLVERILDQAGAKGTGKWTVEMALSIGAPVPTIGAAVDARNISSTKEERVAASTVLDAGLLPSTADEESYVTTMQEALYCAILITYAQALSLLDKLSAERNYNLDLAAVASLWRAGCIIRAGFLDDISKALQEQPDKSNLLLCEPFRTEVANRLPSLRKVVIAATQHGIPVPAFTSALQYYDAYRTATLPANIIQGLRDCFGAHTYKRTDRPGSFHTEWI |
Sequence similarities
Belongs to the 6-phosphogluconate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length468
- Mass (Da)50,277
- Last updated2023-06-28 v1
- ChecksumC62F4FC177B3ED38
Keywords
- Technical term