A0A9J7HXF1 · A0A9J7HXF1_BRAFL
- ProteinMitogen-activated protein kinase kinase kinase kinase
- GeneLOC118408897
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids914 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 24-32 | ATP (UniProtKB | ChEBI) | |||
Binding site | 47 | ATP (UniProtKB | ChEBI) | |||
Active site | 138 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase kinase kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Cephalochordata > Leptocardii > Amphioxiformes > Branchiostomatidae > Branchiostoma
Accessions
- Primary accessionA0A9J7HXF1
Proteomes
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-275 | Protein kinase | |||
Region | 292-366 | Disordered | |||
Compositional bias | 311-366 | Basic and acidic residues | |||
Region | 394-524 | Disordered | |||
Compositional bias | 407-424 | Polar residues | |||
Compositional bias | 481-500 | Acidic residues | |||
Compositional bias | 501-516 | Pro residues | |||
Domain | 566-887 | CNH | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length914
- Mass (Da)103,047
- Last updated2023-06-28 v1
- ChecksumC12A9E9DD6E37CFE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 311-366 | Basic and acidic residues | |||
Compositional bias | 407-424 | Polar residues | |||
Compositional bias | 481-500 | Acidic residues | |||
Compositional bias | 501-516 | Pro residues | |||
Keywords
- Technical term