A0A9J6Q9R2 · A0A9J6Q9R2_9ENTR

Function

function

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Activity regulation

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.

Pathway

Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site139substrate
Binding site183ATP (UniProtKB | ChEBI)
Binding site219-224ATP (UniProtKB | ChEBI)
Binding site245K+ (UniProtKB | ChEBI)
Binding site247K+ (UniProtKB | ChEBI)
Binding site250-251ATP (UniProtKB | ChEBI)
Active site251Proton acceptor
Binding site251substrate
Binding site275ATP (UniProtKB | ChEBI)
Binding site281K+ (UniProtKB | ChEBI)
Binding site284K+ (UniProtKB | ChEBI)
Binding site290K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionribokinase activity
Biological ProcessD-ribose catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribokinase
  • EC number
  • Short names
    RK

Gene names

    • Name
      rbsK
    • ORF names
      M8014_21915

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • H19S6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Silvania

Accessions

  • Primary accession
    A0A9J6Q9R2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-284Carbohydrate kinase PfkB

Sequence similarities

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
Belongs to the carbohydrate kinase pfkB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    32,636
  • Last updated
    2023-06-28 v1
  • MD5 Checksum
    EF56277812AC8A95873BE4988FED97CC
MSVFILGSYAKALVMTTDRIPLAGETLIGRDFRQTWGGKGSDMAVQAARLGADVAYAGVVGDDAFGHEFVSLMQQEGVDIRALTLTNALPTGAGLIVKDNEARNIIVVDMGANKLFTPALVDSALAHIQKCNVALAQLEIPLDTALYGLRKAKALGKTTILNPAPARNLRGIDLSAIDYLTPNETEARVALGLAPDDGRSNREIADLLLETGCQYVVMTLGEAGSAVFSQHDTQEIPPCKVDVVDSNGAGDSFNAALAVALDEGKPIAEAVLLANATAALCCTDWETVPSYHCRSDVDAFMKSMNLAEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAMGZK010000055
EMBL· GenBank· DDBJ
MCU6666995.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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