A0A9J6GQU0 · A0A9J6GQU0_HAELO

Function

function

Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function5'-flap endonuclease activity
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA repair
Biological ProcessDNA replication, Okazaki fragment processing
Biological Processreplication fork reversal

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication ATP-dependent helicase/nuclease
  • EC number

Gene names

    • ORF names
      HPB48_011038

Organism names

  • Taxonomic identifier
  • Strain
    • HaeL-2018
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Haemaphysalinae > Haemaphysalis

Accessions

  • Primary accession
    A0A9J6GQU0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain46-239DNA replication factor Dna2 N-terminal
Domain242-347DUF83
Domain591-683DNA2/NAM7 helicase helicase
Domain693-760DNA2/NAM7 helicase helicase
Domain774-857DNA2/NAM7 helicase-like C-terminal

Sequence similarities

Belongs to the DNA2/NAM7 helicase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    890
  • Mass (Da)
    99,122
  • Last updated
    2023-06-28 v1
  • Checksum
    9918EDA6F9DB87E5
MTALNCPCSCYIDAKAPPIFQSLKGTVKAIDKTTPGCVRLSVEKVDSKEVFTCTLKGSWLNEKLNVGDVVYMHSKFSGNCTTLESDDGLIIVHPDILVNSTTIVSSLFCTRKSVLATKFRDIDSSNLSMLIGSIAHELFQKALAGRASKEVMVEIVNTLLQRSDILHDMYSLKANEVEVREQLLKLLPNIMRWMAEYMSTQLSTNPKLGLSVTEVRDIEDNYWCPRLGVKGKVDATLEVKIHDRQRLLPLELKTGRHTFSAEHKGQVILYTLMMAERQATDVDEGLLLYIRDGVDMQKVASRHAERRDLVQRRNELAAHLASTSCALPDPLDSERFCPKCPYSTTCSIYRRSSSSEETKLKAGTQPEPKFVEESVKHLTSEHMQYFMEWCAMLDTEMQHAKHDLQDCFWVEDAVKRESKGLCFSDMQLVMSQGKSALDARGQAVFQHTFRRKTHHEHPADVPSSASGSFTRCAGLAVGDRVAISEQGSLTCVALALGSVAAVADDEVTLHLERQVWDMRLHPEWQAKTFRIDKTHSAAAFTISYSNLAKLMSSEPASAKLRSLVIDRVLPCYRKTLAKETAVACHSVLKPLNNFQRRAILKFLMSDDYVLFKGLPGTGKTTTIAALIQALVLLKKRVLLTSYTHSGVDSVLLKLKSRSVPFVRLGAADRAHPAVKEFSAGNLTASIKTLKELQEFYESQPVVACTCLGSGQGVLQRLRFDACIVDEASQALQPSCLGPLFLARSFVLVGDTQQLPPVVQSPEASDRETMQLTCREEVGVIAPFRNQVRLLKQECSSVPQVDISTVDQFQGKEKSVVLFSCVKKYTGDSKDAEILNDQRRLTVAVSRAKHKLIIIGSSSTVKKYKPFEKLLSLLREDQFIKLQAGDESRCE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABSTR010000008
EMBL· GenBank· DDBJ
KAH9377065.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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