A0A9J6G1F2 · A0A9J6G1F2_HAELO

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = glycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionsterol ester esterase activity
Molecular Functiontriacylglycerol lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • ORF names
      HPB48_004382

Organism names

  • Taxonomic identifier
  • Strain
    • HaeL-2018
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Haemaphysalinae > Haemaphysalis

Accessions

  • Primary accession
    A0A9J6G1F2

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Interaction

Subunit

Monomer and homodimer. Interacts with CAVIN1 in the adipocyte cytoplasm. Interacts with PLIN5.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-344Hormone-sensitive lipase N-terminal
Domain365-435Alpha/beta hydrolase fold-3

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    51,240
  • Last updated
    2023-06-28 v1
  • Checksum
    44D994FDD0C1266C
MLCCNSDSEALEDRRSDAAPGNCSLVNMSHLGWSGAGQYEMLAQMVQGNIDYFKDVETETGGKILAHLNCMEELLHDIEELVRPILSSAHLFDLDSETRANGFRSIVTVATRFVGLTVKLCRGLQLKRGSPFFRGDSFVKELDVHVNIMRGIKAGLSILGVMLEHTENGSLFVDENLTFSDLFEKFDSFNPTSFYGRCMGFYYCDAIRRTLRKGHAVLSAYRDHYYQTGSGFGSTTTLLWRVGKYSMDTELRAKQMVEMRRNVHTDFLKAMWSLNEQAFLKKVNKFISASVQVACDVVIPLEQLKLPKTREPSVLVEIPVPSSHGPAAPIRCRLISSSVRDGMQSLLPSNLVNSSTVLPASHGLVLHFHGGGFIAQSAESHEIYLNDWARQVHAPILSVDYSLAPERPYPRALEEVAFVYAWALNNCHKLGTHTPLVCSCGTNLCYASRAKLAAYMYSAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABSTR010000004
EMBL· GenBank· DDBJ
KAH9368883.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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