A0A9J6FWN6 · A0A9J6FWN6_HAELO
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids219 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + NAD+ + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H+
- 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + 2 H+
- pentanal + NAD+ + H2O = pentanoate + NADH + 2 H+
- propanal + NAD+ + H2O = propanoate + NADH + 2 H+
- spermine monoaldehyde + NAD+ + H2O = N-(2-carboxyethyl)spermidine + NADH + 2 H+
- hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+
- imidazole-4-acetaldehyde + NAD+ + H2O = imidazole-4-acetate + NADH + 2 H+
- acrolein + NAD+ + H2O = acrylate + NADH + 2 H+
- butanal + NAD+ + H2O = butanoate + NADH + 2 H+
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-trimethylammoniobutyraldehyde dehydrogenase activity | |
Molecular Function | aminobutyraldehyde dehydrogenase (NAD+) activity |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Haemaphysalinae > Haemaphysalis
Accessions
- Primary accessionA0A9J6FWN6
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-204 | Aldehyde dehydrogenase | ||||
Sequence: QVCSNCTRVYVERPMMDEFLDHLVRATEKLKIGDPADPETTVGATISPEHAARVLSYIEDAKKEGARVLCGGQRVTPADPNLSRGHYLSPCVLADCTDDMRVVREEVFGAVASVLPFDTEEEALRRANDSPFGLAAGVMTRDLRRAHRVARRLQAGIVWINNFNVLPAGVPFGGYKMSGYGRENGLAALQAYSQEKAV |
Family and domain databases
Sequence
- Sequence statusComplete
- Length219
- Mass (Da)24,049
- Last updated2023-06-28 v1
- Checksum325327BB138E9324
Keywords
- Technical term