A0A9J6FNV7 · A0A9J6FNV7_HAELO

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • ORF names
      HPB48_010499

Organism names

  • Taxonomic identifier
  • Strain
    • HaeL-2018
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Haemaphysalinae > Haemaphysalis

Accessions

  • Primary accession
    A0A9J6FNV7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
Cell projection, axon
Cytoplasmic granule
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Synapse

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-42Helical
Transmembrane80-100Helical
Transmembrane106-130Helical
Transmembrane137-158Helical
Transmembrane164-182Helical
Transmembrane189-208Helical
Transmembrane388-409Helical
Transmembrane415-432Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region246-362Disordered
Compositional bias260-292Polar residues
Compositional bias301-319Basic and acidic residues
Compositional bias342-356Basic and acidic residues

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    48,764
  • Last updated
    2023-06-28 v1
  • Checksum
    10213C81FB299328
MAQERPRVPADVVWGVLDDALVHVVRILAAVSCCMLLVVITVRINPQFLDSQGATLPYTPLPDTEEQTTVARASNAAGNALILIGVVIFMTTLMVSLYYYHFYKVIAVWITCACVLILLMTSNTYISLIFKTYNVPADYFSVGFFVYNFTALGLVVILSQGPLILQQLYLVIESAFMALMLITYLPPYTIWVVLVVVPIWDLVAVLAVHGPLRILVETAKERKEALQPGLVFATIVVGTFPAMASRHHGSSAAGRPSGDRGRSSESQPVGRLSPNVTPEGQDTSNRRTTNVKPTHRSNSHRRPLHATDTAPKPHDDTIRPGPRVFSPPKRAAKVPTETDLPVGPPKRDDADSDSSSDGGQERQGIKMGLGDFVFYSVLVGKVATFGDWAIVAACFVGILVGICVTLALLAVTQSALPALPVSLAFGLLFAGLQQSVQNFLNEVSLKHAFI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias260-292Polar residues
Compositional bias301-319Basic and acidic residues
Compositional bias342-356Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABSTR010000002
EMBL· GenBank· DDBJ
KAH9364120.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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