A0A9E9NIX6 · A0A9E9NIX6_CRIPL
- ProteinStress-activated protein kinase JNK
- GeneJNK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids402 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | JUN kinase activity | |
Molecular Function | protein serine kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameStress-activated protein kinase JNK
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Palaeoheterodonta > Unionida > Unionoidea > Unionidae > Anodontinae > Cristaria
Accessions
- Primary accessionA0A9E9NIX6
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 24-320 | Protein kinase | ||||
Sequence: YQNLRPIGSGAQGIVCAAYDRETDQNVAIKKLSRPFQNVTHAKRAYREFVLMKLVNHKNIIGLLNAFTPQKSLEEFQDVYLVMELMDANLCQVIQMDLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTGFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAELIRGGVMFPGSDHIDQWNKIIEQLGTPSQDFMKRLQTTVRNYVENRPKYPGYSFEKLFPDVLFPPDSTEHPGLRSTMARDLLSKMLVVDPEKRISVDEALMHPYI | ||||||
Region | 366-402 | Disordered | ||||
Sequence: GKQKASMQSHAVPDGANNDTPAMDSVGSENATQNHCR | ||||||
Compositional bias | 367-402 | Polar residues | ||||
Sequence: KQKASMQSHAVPDGANNDTPAMDSVGSENATQNHCR |
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length402
- Mass (Da)45,862
- Last updated2023-05-03 v1
- ChecksumCD493CD8E18D4931
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 367-402 | Polar residues | ||||
Sequence: KQKASMQSHAVPDGANNDTPAMDSVGSENATQNHCR |