A0A9E8D5V0 · A0A9E8D5V0_9GAMM

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site129-131(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site233Plays an important role in substrate specificity
Binding site251(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site360-362(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      OM794_20505

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BDJS001
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halomonas

Accessions

  • Primary accession
    A0A9E8D5V0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue234N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-391Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    437
  • Mass (Da)
    47,157
  • Last updated
    2023-05-03 v1
  • Checksum
    95136A835D47409C
MLHNNFSPNARLASYDTLLAEAIAEETVRQEAHIELIASENYTSKLVMEALGTQLTNKYAEGYPDRRYYGGCEFVDKVEALAIERACHLFSANYANVQPHSGAQANAAVFMALVSPGDTVLGMSLAHGGHLTHGAAPNFSGKHYNAVQYGLKPETGEIDYEEVERLAREHQPKMIIAGFSAYSRVVDWRRFRAIADEVGAWLMVDMAHVAGLVAAGLYPSPLPFAHVVTTTTHKTLRGPRGGLILSAHGDEALYKKLNGAVFPGQQGGPLMHVIAAKAVAFKEAMNQEFVRYQQQVIDNAQAMAKVFMERGYDVVSGGTDDHLFLVSLIRQGITGKDADAALGRAHITVNKNTVPNDPQSPFVTSGLRIGTPAVTTRGFDAEECSELAGWICDILDELAAGKDTTSIEAEVQAKVTDVCAQHPVYAESAAEAVESIA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP110535
EMBL· GenBank· DDBJ
UZH09683.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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