A0A9E7D6F3 · A0A9E7D6F3_9ACTO
- ProteinRibonuclease H
- GenernhA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids301 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity
Cofactor
Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleic acid binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | DNA replication, removal of RNA primer |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease H
- EC number
- Short namesRNase H
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Actinomycetales > Actinomycetaceae > Actinomyces
Accessions
- Primary accessionA0A9E7D6F3
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-138 | RNase H type-1 | ||||
Sequence: MTTVVAVDGSALGNPGPAGWAWYVDENCWAAGGWPSSSNNRGELTALLELLKATASTNEELHVLADSQYVINSVTKWMSGWKKRGWRKSDKSPVLNADLMQAIDKAITGRKVSFEWVRGHSGHPLNEAADDKARAAAT | ||||||
Region | 130-182 | Disordered | ||||
Sequence: DDKARAAATAYQRHVSVESGPGWTRGENKGTTTTAPGSAQGSTAVPGSAQGAN | ||||||
Compositional bias | 154-179 | Polar residues | ||||
Sequence: RGENKGTTTTAPGSAQGSTAVPGSAQ | ||||||
Region | 196-215 | Disordered | ||||
Sequence: PRTAAHASSRVGTSTSQPQQ | ||||||
Coiled coil | 217-279 | |||||
Sequence: VTALQQQIAQTQREIASEQQKIVAAHQSIVTIQQNITAAQQKIAKIQQKIASAQQTVTSAQQE | ||||||
Region | 282-301 | Disordered | ||||
Sequence: SANRHGGRAKSADPNPDTLF |
Sequence similarities
Belongs to the RNase H family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length301
- Mass (Da)31,926
- Last updated2023-05-03 v1
- Checksum168C92AB1F735B3E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 154-179 | Polar residues | ||||
Sequence: RGENKGTTTTAPGSAQGSTAVPGSAQ |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP097095 EMBL· GenBank· DDBJ | UQF79398.1 EMBL· GenBank· DDBJ | Genomic DNA |