A0A9E7D6F3 · A0A9E7D6F3_9ACTO

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Features

Showing features for binding site.

130120406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site8Mg2+ 2 (UniProtKB | ChEBI)
Binding site8Mg2+ 1 (UniProtKB | ChEBI)
Binding site43Mg2+ 1 (UniProtKB | ChEBI)
Binding site66Mg2+ 1 (UniProtKB | ChEBI)
Binding site130Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      rnhA
    • ORF names
      M3I41_07360

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCVI-JB-Ag32
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Actinomycetales > Actinomycetaceae > Actinomyces

Accessions

  • Primary accession
    A0A9E7D6F3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain1-138RNase H type-1
Region130-182Disordered
Compositional bias154-179Polar residues
Region196-215Disordered
Coiled coil217-279
Region282-301Disordered

Sequence similarities

Belongs to the RNase H family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    31,926
  • Last updated
    2023-05-03 v1
  • Checksum
    168C92AB1F735B3E
MTTVVAVDGSALGNPGPAGWAWYVDENCWAAGGWPSSSNNRGELTALLELLKATASTNEELHVLADSQYVINSVTKWMSGWKKRGWRKSDKSPVLNADLMQAIDKAITGRKVSFEWVRGHSGHPLNEAADDKARAAATAYQRHVSVESGPGWTRGENKGTTTTAPGSAQGSTAVPGSAQGANFPSRAEAAMTPGLPRTAAHASSRVGTSTSQPQQNVTALQQQIAQTQREIASEQQKIVAAHQSIVTIQQNITAAQQKIAKIQQKIASAQQTVTSAQQEILSANRHGGRAKSADPNPDTLF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias154-179Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP097095
EMBL· GenBank· DDBJ
UQF79398.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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