A0A9E0WZV8 · A0A9E0WZV8_UNCPS
- ProteinPhosphoribosylformylglycinamidine synthase
- GenepurL
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1378 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Catalytic activity
- ATP + H2O + L-glutamine + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N1-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H+ + L-glutamate + phosphate
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 735 | ATP (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 736 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 775 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 779 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 944 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 946 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Active site | 1222 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 1343 | |||||
Sequence: H | ||||||
Active site | 1345 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoribosylformylglycinamidine synthase activity | |
Biological Process | 'de novo' IMP biosynthetic process | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosylformylglycinamidine synthase
- EC number
- Short namesFGAM synthase ; FGAMS
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota
Accessions
- Primary accessionA0A9E0WZV8
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 86-206 | Phosphoribosylformylglycinamidine synthase N-terminal | ||||
Sequence: HVHWVWSDAALVPADHDKLAALLRYGDPYAGPNDGALLVVAPRLGTVSPWASKATDIAHNCGLDVVHRVERVTEYRLELKNPLLGSAKPLAPDERQAAAALLHDRMTESVLYERQAAAHLF | ||||||
Domain | 228-276 | Phosphoribosylformylglycinamidine synthase linker | ||||
Sequence: VAANRDFGLALSDDEIDYLVDAFAALKRNPTDVELMMFAQANSEHCRHK | ||||||
Domain | 491-648 | PurM-like C-terminal | ||||
Sequence: PGTLLIQLGGPGMRIGMGGGAASSMAAGANAAELDFDSVQRGNPEIQRRAQEVINHCWALGDGNPILAIHDVGAGGLSNAFPELVDGAGRGARFDMAKVPLEESGLAPKEVWCNESQERYVLAVAPEALPLFKAMCERERCPYAVVGTATDETELILQ | ||||||
Domain | 877-1052 | PurM-like C-terminal | ||||
Sequence: PGDTTLVLIDLGQGRHRLGGSMLAQVLGQTGSVAADGVPDLDDPALLKALVAAINRLRADGRLLAYHDRSDGGLWATVCEMAFAGHLGVSLNVDLLVTEGDGIGDSRAEYGDSKNWASQVSARREELTLRALFAEELGAVIQVPTALRNDVMQTLREHGLSKHSHFVGKTNDRGIV |
Sequence similarities
In the N-terminal section; belongs to the FGAMS family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,378
- Mass (Da)148,210
- Last updated2023-05-03 v1
- Checksum5EB6D0B4586C7D50