A0A9E0TA86 · A0A9E0TA86_UNCPS

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site32NADPH (UniProtKB | ChEBI)
Binding site49NADPH (UniProtKB | ChEBI)
Binding site104NADPH (UniProtKB | ChEBI)
Binding site104sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site104substrate
Binding site132sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site134sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site136NAD+ (UniProtKB | ChEBI)
Binding site136NADPH (UniProtKB | ChEBI)
Active site187Proton acceptor
Binding site187sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site240sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site250sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site251NAD+ (UniProtKB | ChEBI)
Binding site251NADPH (UniProtKB | ChEBI)
Binding site251sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site251-252substrate
Binding site252sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site275NADPH (UniProtKB | ChEBI)
Binding site277NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      JSR53_14485

Organism names

Accessions

  • Primary accession
    A0A9E0TA86

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_503897576423-329Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-155Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain176-316Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    33,763
  • Last updated
    2023-05-03 v1
  • Checksum
    0168030B91E31153
MKIVVLGAGAWGTALAVSAAHASAHAVTLWARDAQQAATMQAARCNQRYLPGVAFPPALQVVAGDARALAAGAELVIIATPMAALRDMLQLLAGCQAPIAWLCKGFEAGTGLMAHEVCAQVAPQLASGVLSGPSFALEVARAQPTALVAASARERVREALVAAFHGHMLRVYASDDIVGVEVGGAVKNVLAIATGLCDGLQLGLNARAALITRGLAEMTRLGLALGARPDTFMGLSGLGDLVLTATGDLSRNRRVGLLLAGGQTLQQAVASLGHVAEGVYSARTVVQRARAAGVEMPIAECVVALLDGRLRAADAVALLMEREPTVERH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFEES010000383
EMBL· GenBank· DDBJ
MBS0508579.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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