A0A9D5KFQ9 · A0A9D5KFQ9_9BACT

Function

function

APS kinase catalyzes the synthesis of activated sulfate.
Catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-19GTP (UniProtKB | ChEBI)
Binding site89-93GTP (UniProtKB | ChEBI)
Binding site144-147GTP (UniProtKB | ChEBI)
Binding site463-470ATP (UniProtKB | ChEBI)
Active site537Phosphoserine intermediate

GO annotations

AspectTerm
Molecular Functionadenylylsulfate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processphosphorylation
Biological Processsulfate assimilation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Sulfate adenylyltransferase subunit 1
  • EC number
  • Alternative names
    • ATP-sulfurylase large subunit
    • Sulfate adenylate transferase
      (SAT
      )
  • Recommended name
    Adenylyl-sulfate kinase
  • EC number
  • Alternative names
    • APS kinase
    • ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
    • Adenosine-5'-phosphosulfate kinase

Gene names

    • Name
      cysN
    • Synonyms
      cysC
    • ORF names
      GF410_12310

Organism names

Accessions

  • Primary accession
    A0A9D5KFQ9

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer composed of CysD, the smaller subunit, and CysN.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-219Tr-type G

Sequence similarities

Belongs to the APS kinase family.
In the C-terminal section; belongs to the APS kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    70,178
  • Last updated
    2023-05-03 v1
  • Checksum
    EB5C03B1C1F536AF
MEKSLLRLTTSGSVDDGKSTLIGRLLFETKCVYEDQLAAVHKASQKKGLAETDLALLLDGLAAEREQGITIDVAYRYFETPKRKFIIADCPGHEQYTRNMVTGASTAQLALILIDARNGVLTQSKRHGFLVSLLQIPHLVVAVNKMDLMDYREDVYNDIVAEYSAFSEKLDIHDITYIPVSALKGDNVVDKSPNMTWYQGFPLLKYLESVHVAADHNLVDFRFPVQYVIRPHLDFRGYAGRVSSGTVRVGEEIAVLPSGKTSRVRGVTTFDGELDEAFVTQSVVLSLEDEIDISRGDMIVRKNNLPEVGNRVEAIICWMSEEASSESTAYILKHTTKNTKAFISKINYKIDVNTLHREQAGNLTLNEIARVEIRTAQPLFFDAYDSNRATGSFILIDPHTNLTVAGGMIRSASRDLESVTAASLDQHIARKSSTNVTWQSLSTARRKREDRQGHRAAVLWLTGYSGSGKSTIAKALEKRLFDMGCSTMLLDGDNVRHGLCGDLGFSDRDRTENIRRVGEVAKLFFENGALAICTFISPFREDRDFVRGIMEPGRFFEVFVKCDLEVCKRRDPRGLYKKAAAGEIKQFTGIDSPYEEPVHPELTVETDLESADQIVESIIGALREKGILGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WJMI01000272
EMBL· GenBank· DDBJ
MBD3392794.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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