A0A9D5KE02 · A0A9D5KE02_9BACT

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site18ATP (UniProtKB | ChEBI)
Binding site80-81ATP (UniProtKB | ChEBI)
Site118Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site140-142substrate; ligand shared between dimeric partners; in other chain
Active site142Proton acceptor
Binding site177substrate; ligand shared between dimeric partners
Binding site184-186substrate; ligand shared between dimeric partners; in other chain
Binding site237substrate; ligand shared between dimeric partners; in other chain
Binding site306substrate; ligand shared between dimeric partners
Binding site312-315substrate; ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Cellular Component6-phosphofructokinase complex
Molecular Function6-phosphofructokinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionfructose-6-phosphate binding
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmonosaccharide binding
Biological Processcanonical glycolysis
Biological Processfructose 1,6-bisphosphate metabolic process
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      pfkA
    • ORF names
      GF410_09580

Organism names

Accessions

  • Primary accession
    A0A9D5KE02

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain11-338Phosphofructokinase
Region249-276Disordered

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    41,643
  • Last updated
    2023-05-03 v1
  • Checksum
    9C748909A4FBBE65
MTRKKSKTKCIGILTSGGDCPGLNAAIRGIAKAAMNEYGMQVIGIMDGFRGLVENRTIPLEDRAVSGILTTGGTVLGTSRDKIHKMPMGGKKMDMTSVAVQNAKRLHIDCLVCLGGGGTQKNALHLHEQGGLSVVTLPKTIDNDVPGTDVSFGFDTALKTATEAIDRLHTTATSHHRIIVVEVMGHNAGWLTLGAGIAGGADVILIPEIPYDLDVVAEHLLERRRSAKRFSIIAVAEGAVSKEEAAHIAAEKKSGKKAKNKEKKKHKKDQRRAEANAEHLPYHLVRESKASSLARKLQQFTGTEGRVTSLGHMQRGGIPSATDRALCTQLGTKAAELLADGTYNVMVAMRGGVCKAVPLESVAGKRKTVPMNHPWIRAAMLVGTCLGDYL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WJMI01000206
EMBL· GenBank· DDBJ
MBD3392252.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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