A0A9D4YHL6 · A0A9D4YHL6_PEA
- ProteinDNA replication licensing factor MCM7
- GeneMCM7
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids458 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | MCM complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | RNA binding | |
Molecular Function | single-stranded DNA binding | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA replication initiation | |
Biological Process | DNA strand elongation involved in DNA replication | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | double-strand break repair via break-induced replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication licensing factor MCM7
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > Hologalegina > IRL clade > Fabeae > Pisum
Accessions
- Primary accessionA0A9D4YHL6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 19-39 | Disordered | ||||
Sequence: RPRRKYKNSRPKVRVGLPKKN | ||||||
Compositional bias | 23-37 | Basic residues | ||||
Sequence: KYKNSRPKVRVGLPK | ||||||
Region | 92-125 | Disordered | ||||
Sequence: PSVSDDPNDSGSDLEEDDLKSALGKRRRDGKSAL | ||||||
Compositional bias | 105-123 | Basic and acidic residues | ||||
Sequence: LEEDDLKSALGKRRRDGKS | ||||||
Domain | 183-229 | RRM | ||||
Sequence: LIIFVGGLNPNVTDEDLRQTFSEYGEITSVKIPVGKGCGFVQFANSK | ||||||
Domain | 404-444 | MCM | ||||
Sequence: IYDKLARSLAPEIFGHEDIKKALLLLLVGAPHRQLKDGMKV |
Sequence similarities
Belongs to the MCM family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length458
- Mass (Da)52,126
- Last updated2023-05-03 v1
- Checksum4E1A4B1EE1F69106
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9D4YGP7 | A0A9D4YGP7_PEA | KIW84_024884 | 146 | ||
A0A9D5AXZ8 | A0A9D5AXZ8_PEA | MCM7 | 442 | ||
A0A9D5B3R2 | A0A9D5B3R2_PEA | KIW84_033419 | 109 | ||
A0A9D4Y041 | A0A9D4Y041_PEA | KIW84_033419 | 108 | ||
A0A9D4YIZ9 | A0A9D4YIZ9_PEA | KIW84_024884 | 130 | ||
A0A9D4YLA5 | A0A9D4YLA5_PEA | MCM7 | 449 | ||
A0A9D4YML9 | A0A9D4YML9_PEA | KIW84_024884 | 167 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-37 | Basic residues | ||||
Sequence: KYKNSRPKVRVGLPK | ||||||
Compositional bias | 105-123 | Basic and acidic residues | ||||
Sequence: LEEDDLKSALGKRRRDGKS |
Keywords
- Technical term