A0A9D4W706 · A0A9D4W706_PEA
- ProteinDNA-(apurinic or apyrimidinic site) endonuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids549 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 295 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 326 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 402 | |||||
Sequence: Y | ||||||
Active site | 442 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 442 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 444 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 444 | Transition state stabilizer | ||||
Sequence: N | ||||||
Site | 514 | Important for catalytic activity | ||||
Sequence: D | ||||||
Binding site | 539 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 540 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 540 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 540 | Interaction with DNA substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | carbohydrate binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA-(apurinic or apyrimidinic site) endonuclease
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > Hologalegina > IRL clade > Fabeae > Pisum
Accessions
- Primary accessionA0A9D4W706
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 103-137 | SAP | ||||
Sequence: VETMTVPELRKTLKSIGVPAKGRKEDLLSALKNFM |
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Belongs to the leguminous lectin family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length549
- Mass (Da)62,191
- Last updated2023-05-03 v1
- ChecksumF1A9DF5A99E9C86E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A9D4W7H8 | A0A9D4W7H8_PEA | KIW84_062671 | 514 | ||
A0A9D4W5M5 | A0A9D4W5M5_PEA | KIW84_062671 | 477 |
Keywords
- Technical term