A0A9D4P6K1 · A0A9D4P6K1_DERFA
- ProteinTryptophan 2,3-dioxygenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1777 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Catalytic activity
- L-tryptophan + O2 = N-formyl-L-kynurenine
Cofactor
Note: Binds 1 heme group per subunit.
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell presynaptic membrane | |
Cellular Component | other organism cell membrane | |
Cellular Component | plasma membrane | |
Molecular Function | chitin binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | toxin activity | |
Molecular Function | tryptophan 2,3-dioxygenase activity | |
Biological Process | exocytosis | |
Biological Process | tryptophan catabolic process to acetyl-CoA | |
Biological Process | tryptophan catabolic process to kynurenine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTryptophan 2,3-dioxygenase
- EC number
- Short namesTDO
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides
Accessions
- Primary accessionA0A9D4P6K1
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer. Dimer of dimers.
Structure
Family & Domains
Features
Showing features for repeat, compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 564-596 | ANK | |||
Repeat | 658-690 | ANK | |||
Repeat | 691-723 | ANK | |||
Repeat | 724-756 | ANK | |||
Compositional bias | 801-824 | Polar residues | |||
Region | 801-832 | Disordered | |||
Region | 876-970 | Disordered | |||
Compositional bias | 891-917 | Polar residues | |||
Compositional bias | 918-932 | Basic and acidic residues | |||
Compositional bias | 933-966 | Polar residues | |||
Region | 1336-1365 | Disordered | |||
Region | 1438-1637 | Disordered | |||
Compositional bias | 1454-1469 | Polar residues | |||
Compositional bias | 1513-1532 | Polar residues | |||
Domain | 1692-1752 | Chitin-binding type-2 | |||
Sequence similarities
Belongs to the tryptophan 2,3-dioxygenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,777
- Mass (Da)198,267
- Last updated2023-05-03 v1
- MD5 Checksum83571853FC8A3BB1944E72A3D8826E39
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 801-824 | Polar residues | |||
Compositional bias | 891-917 | Polar residues | |||
Compositional bias | 918-932 | Basic and acidic residues | |||
Compositional bias | 933-966 | Polar residues | |||
Compositional bias | 1454-1469 | Polar residues | |||
Compositional bias | 1513-1532 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
SDOV01000001 EMBL· GenBank· DDBJ | KAH7644822.1 EMBL· GenBank· DDBJ | Genomic DNA |