A0A9D4NPE2 · A0A9D4NPE2_DERFA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionsterol esterase activity
Molecular Functiontriglyceride lipase activity
Biological Processcholesterol metabolic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • ORF names
      HUG17_10194

Organism names

  • Taxonomic identifier
  • Strain
    • JKM2019
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Astigmata > Psoroptidia > Analgoidea > Pyroglyphidae > Dermatophagoidinae > Dermatophagoides

Accessions

  • Primary accession
    A0A9D4NPE2

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-249Hormone-sensitive lipase N-terminal
Domain319-477Alpha/beta hydrolase fold-3

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    637
  • Mass (Da)
    74,056
  • Last updated
    2023-05-03 v1
  • Checksum
    95A9BC1B30CB3BB7
MALNSYLCNFIQSPVGYAFDIEKARIDNDRSISDQLDQVFHTLTVIYADDVELIDYIQRIRHDVDLVLQQAPLFDLDDQTQGNGYWTLLIIMIKFGRILSTPDLKKKIGRLPLIHLMQIMVEGLKVGLQLHTPKLKSMQQIDSNGKVDLSLFTDEMDFEGILDLIQSLKVPMNSLHEHFNFCWLGSMSKVMQLFTNFMAIYSTQWKSFKIYNWLSHKARAQMFTNMVLNVNVDCLQSMWNITEFPLVRIFTPSFWNRFILENINIYAPRQRRWIIDATKPIIHDRRADPNVPYPIMKQSSIRGLLFRYRHNPKNKSLMFHLHGGGFISQSPESHACYLVKWVRKLDDIPILSVDYSLSPQVIFPEALQEILDMYLWILSKDPEVEKTFGFLPEKIVFCGDSAGGNFSMAMMLILNQIQKKIAESEDKQKYRYPNGLFLFYAPLVVATMVSPSRILTSIDGLIPLGTLLNCLGAYLPDEIFEDNLPKEENIDYANGKETVAYQVGGYFINKLKDVLSYLLQLKVVYRIKPWYRRTGNLKKCLDKMNTFVQNPFVSPLLAESVKDFNHIPLYLYPLTFDAFLDDSIEMAKRWQKDKVKVEILDDLPHGFLNFVEFDYKARKASYKCIDRISEILKHIDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SDOV01000010
EMBL· GenBank· DDBJ
KAH7636224.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp