A0A9D3XDT7 · A0A9D3XDT7_9SAUR
- ProteinRho-associated protein kinase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1346 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | bleb | |
Cellular Component | centriole | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | Golgi membrane | |
Cellular Component | lamellipodium | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | Rho-dependent protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actomyosin structure organization | |
Biological Process | cortical actin cytoskeleton organization | |
Biological Process | embryonic morphogenesis | |
Biological Process | mitotic cytokinesis | |
Biological Process | regulation of cell junction assembly | |
Biological Process | Rho protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Testudinoidea > Geoemydidae > Geoemydinae > Mauremys
Accessions
- Primary accessionA0A9D3XDT7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-307 | Protein kinase | ||||
Sequence: YEVVKVIGRGAFGEVQLVRHKSSRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKAGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGQECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKDAKNLICAFLTDREVRLGRNGVEEIKRHLFF | ||||||
Domain | 310-378 | AGC-kinase C-terminal | ||||
Sequence: DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSTHRCLSAS | ||||||
Coiled coil | 396-869 | |||||
Sequence: LENMQKTIYQLEEQLQNEMQLKDEMEQKCRTSNIKLDKLMKELDEEGNQRKNLESTVSQTEKEKMLLQHKINEYQRKAEQENEKRRNVENEVSTLKDQLEDMKKISQHSQTTNEKMTQLQKQLEEANDLLRTESDTAARLRKSHTEMSKSISQLESLNRELQERCRVLESTKLEVEKDYYQLQAALEAERRDRSHGSEMIGDLQARITSLQEEVKNLKNNLERVEAERKQAQDSLNHCEKEKNNLEIDLNYKLKTLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKVKEERAARDRAENQIVQIEKQCSMLDFDLKQSQQKLEHLTEQKERLKDEVKTLKHQLEQETNKRLMTQNELKTQAFEADNLKGSEKQLKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNKETQRKIQELQNEKETLAAQLDLAETK | ||||||
Domain | 450-527 | REM-1 | ||||
Sequence: STVSQTEKEKMLLQHKINEYQRKAEQENEKRRNVENEVSTLKDQLEDMKKISQHSQTTNEKMTQLQKQLEEANDLLRT | ||||||
Coiled coil | 909-950 | |||||
Sequence: VSRLEETNNTLTNDVEFLTKENAELIEKNKKQEEEFKLKKEE | ||||||
Domain | 920-986 | RhoBD | ||||
Sequence: TNDVEFLTKENAELIEKNKKQEEEFKLKKEEEINNIRMHYEKNLQTERTLKTQAVNKLAEIMNRKDF | ||||||
Coiled coil | 991-1071 | |||||
Sequence: KKANVQDLRKKEKENRKLQLELNQEKEKYNQMVVKYQKELNEMQAQLAEESTYRNELQMQLDSKESDIEQLRSKLLDLQQG | ||||||
Domain | 1091-1290 | PH | ||||
Sequence: ESRIEGWLSIPNKGNIKRHGWKKQYVVVSSKKILFYNDEKDKDLSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDLEAEPAQTVEKTNFLNHKGHEFIPTLYHFPANCEACSKPLWHVFKPPPALECRKCHVKCHKDHLDKKEELITPCKVSYDVTSARDMLLLASCQDEQKKWVTHLVKKIP | ||||||
Domain | 1201-1256 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPANCEACSKPLWHVFKPPPALECRKCHVKCHKDHLDKKEELITPC | ||||||
Compositional bias | 1303-1321 | Polar residues | ||||
Sequence: RTLSARSSANQSFRKGVKN | ||||||
Region | 1303-1346 | Disordered | ||||
Sequence: RTLSARSSANQSFRKGVKNTSGKTRSKDCESMGESTLSENSSYC |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,346
- Mass (Da)157,027
- Last updated2023-05-03 v1
- ChecksumFB1CCA48D549A25D
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: D | ||||||
Compositional bias | 1303-1321 | Polar residues | ||||
Sequence: RTLSARSSANQSFRKGVKN |
Keywords
- Technical term