A0A9D2EU93 · A0A9D2EU93_UNCFI
- ProteinLon protease
- Genelon
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids766 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Catalytic activity
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 350-357 | ATP (UniProtKB | ChEBI) | |||
Active site | 673 | ||||
Active site | 716 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | cellular response to heat | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLon protease
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota
Accessions
- Primary accessionA0A9D2EU93
Proteomes
Subcellular Location
Expression
Induction
By heat shock.
Interaction
Subunit
Homohexamer. Organized in a ring with a central cavity.
Structure
Sequence
- Sequence statusComplete
- Length766
- Mass (Da)85,214
- Last updated2023-05-03 v1
- ChecksumB527815E594AD9F1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DXBQ01000023 EMBL· GenBank· DDBJ | HIZ43555.1 EMBL· GenBank· DDBJ | Genomic DNA |