A0A9D1VUY4 · A0A9D1VUY4_9FIRM
- ProteinDiaminopimelate epimerase
- GenecarB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1102 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Catalytic activity
- (2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 835 | substrate | |||
Binding site | 886 | substrate | |||
Binding site | 896-897 | substrate | |||
Binding site | 984 | substrate | |||
Site | 986 | Could be important to modulate the pK values of the two catalytic cysteine residues | |||
Binding site | 1017 | substrate | |||
Site | 1035 | Could be important to modulate the pK values of the two catalytic cysteine residues | |||
Binding site | 1035-1036 | substrate | |||
Active site | 1044 | Proton acceptor | |||
Binding site | 1045-1046 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
Molecular Function | diaminopimelate epimerase activity | |
Molecular Function | metal ion binding | |
Biological Process | glutamine metabolic process | |
Biological Process | lysine biosynthetic process via diaminopimelate | |
Biological Process | pyrimidine nucleotide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate epimerase
- EC number
- Short namesDAP epimerase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Christensenellales > Christensenellaceae > Candidatus Borkfalkia
Accessions
- Primary accessionA0A9D1VUY4
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-81 | ATP-grasp | |||
Domain | 420-610 | ATP-grasp | |||
Domain | 681-828 | MGS-like | |||
Sequence similarities
Belongs to the CarB family.
Belongs to the diaminopimelate epimerase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,102
- Mass (Da)122,162
- Last updated2023-05-03 v1
- Checksum3EC7D8DD588EEB0A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DXFD01000099 EMBL· GenBank· DDBJ | HIX47341.1 EMBL· GenBank· DDBJ | Genomic DNA |