A0A9D1VUY4 · A0A9D1VUY4_9FIRM

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site835substrate
Binding site886substrate
Binding site896-897substrate
Binding site984substrate
Site986Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site1017substrate
Site1035Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site1035-1036substrate
Active site1044Proton acceptor
Binding site1045-1046substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondiaminopimelate epimerase activity
Molecular Functionmetal ion binding
Biological Processglutamine metabolic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      carB
    • Synonyms
      dapF
    • ORF names
      H9737_06610

Organism names

Accessions

  • Primary accession
    A0A9D1VUY4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-81ATP-grasp
Domain420-610ATP-grasp
Domain681-828MGS-like

Sequence similarities

Belongs to the CarB family.
Belongs to the diaminopimelate epimerase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,102
  • Mass (Da)
    122,162
  • Last updated
    2023-05-03 v1
  • Checksum
    3EC7D8DD588EEB0A
SIVIAPAVTLSDKEYQMLRSASLKIITELGIEGGCNCQFALNPDSFEYSVIEVNPRVSRSSALASKATGYPIAKVATKIALGYTLDEIRNDVTGKTYACFEPTIDYVVVKLPKWPFDKFLYAKRELGTRMKATGEVMSIGTSFEMAIMKAVRGAEISLSSLNLDKYEGKDLREELKKLSDERLFTVYAALKADISVDEIFEITKIDRWFLNKLKNLVEYERRLRSEKLTRALYDEGKRLGYPDHELEALSGQKIPYHRKAVYKMVDTCAAEFAAETPYFYSTYDEYAHDEATPFIKESTKKRIIVIGSGHIRIGQGIEFDYSSVHCVWTLKELGYEVIIINNNPETVSTDFDTADRLYFEPLTPEDVQNVIDKEKPYGVVITFGGQTAIKLCNYLDKKGIRILGTSADSVDMAEDRERFDELLERFGISRPKGLTVMTKEEALHAADTLGYPVLLRPSYVIGGQNMTIAFTESDISRYMDVILAQHIENPVLCDKYLMGQELEVDVISDGVDVLIPGIMQHIERAGVHSGDSIAVYPPYNLSDIMLDKIIECSTQLALSLKTKGLINIQFLVYHNELYVIEVNPRASRTIPYISKVTGVPMVELATKIMVGAKLKKLGYGTGLYKTSPYVAVKVPVFSFEKLNDVNSQLGPEMKSTGEVLGMGKTIEEALFKGLVSAGFKLCHPSKQREVGVYFTVNDQDKFEILGLAKKFSDLGLRLYATAGTADTIRTLDIDVTTVDRLSQSDEIMRLMDDGKIDYIVYTGKTDMASIDDYIRMHHHAILLGITTLTSLDTANALADIIASRFTEDNTELVDINALRPEKTQLSFVKMQSCGNDYIFFDNMDGKITCPESLAINFVDRHYGIGGDGIVLIEKSNVADAKMRIFNKDGSEGAMAGNSIRCVAKYLFDKGFVHDKKITIETLSGVRELTLYTFSGKVGSVSVDMGKAVLDGAAIPSTLEGETVVGRPIEVGGQEYKVTLVNVGNPHCVVFCNKVDAVDVANVGPLFEHAEYFPQRINAEFVRVVNEKTLKMRVWERGNGETLACGTGAAASVVAAVLNGYCKPDEDITVKLRGGDLIVRYSSDGRVTLTGSVRLVYAGTVEF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DXFD01000099
EMBL· GenBank· DDBJ
HIX47341.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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