A0A9D1N8U3 · A0A9D1N8U3_9FIRM

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site11
Active site130

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisF
  • EC number
  • Alternative names
    • IGP synthase cyclase subunit
    • IGP synthase subunit HisF
    • ImGP synthase subunit HisF
      (IGPS subunit HisF
      )

Gene names

    • Name
      hisF
    • ORF names
      IAC73_00895

Organism names

Accessions

  • Primary accession
    A0A9D1N8U3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Family & Domains

Sequence similarities

Belongs to the HisA/HisF family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    26,671
  • Last updated
    2023-05-03 v1
  • Checksum
    7C2F5E7AA516A061
MLAKRIIPCLDVRDGRVVKGVNFEGLRDVSSPVDLARYYNDSGADELVFYDIAASAAGRKLFADSLTEVASQVFIPLTVGGGINTLEDFDRVLKCGADKVSVNSGAIADPGLVGRAAKKYGDQCVVLSIDAKREGGVYRVYSKGGRVPTDLDAVEWARRGQEEGAGEIVLNSIDTDGVKDGFDLEMLSDVCAAVSVPVIASGGAGCAEDFVKLFASVPGVDAGLAASIFHFREVDIKDLKLRLKEAGIPVRL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DVOE01000010
EMBL· GenBank· DDBJ
HIU98384.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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