A0A9D1LTL8 · A0A9D1LTL8_9FIRM

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site188[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site195[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site198[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site204[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionendonuclease activity
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • ORF names
      IAB04_00630

Organism names

Accessions

  • Primary accession
    A0A9D1LTL8

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-186HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    213
  • Mass (Da)
    23,773
  • Last updated
    2023-05-03 v1
  • Checksum
    F5B9014DD1A9B0DD
MRKTETVAEIRKIFDAVYPDVQCSLNYKTPLQMLIATQLSAQCTDARVNIVTGPLFERYKTAEDFANADILELQGYIRSAGFYKNKSKNIIACCRRLVDVYGGEVPDNMEDLLTLAGTGRKTANLVLGDIFNKPAVVVDTHCIRLTNRIGLVKEQDPVKIEFALKKIVPEDYQNRFCHQLVMHGRAVCPARSPKCSTCPIQAFCKKIGVKGGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DVND01000014
EMBL· GenBank· DDBJ
HIU47848.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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