A0A9D1EH52 · A0A9D1EH52_9FIRM
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids422 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Lachnospiraceae incertae sedis > Candidatus Egerieimonas
Accessions
- Primary accessionA0A9D1EH52
Proteomes
Interaction
Subunit
Heterodimer of LeuC and LeuD.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-412 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: AGQLIEAELDLVLGNDITSPVAIHEMDKMTVNTVFDKDKIALVMDHFIPNKDIKSAEHCKCVREFACKHEITNYFDVGEMGIEHALLPEKGLTVAGDVIIGADSHTCTYGALGAFSTGVGSTDMAAGMATGKCWFKVPSAIKFNLIGKLPKWVSGKDVILHIIGMIGVDGALYRSMEFVGEGVASLSMDDRFTIANMAIEAGGKNGIFPVDDKAKAYMAEHSKRSYKVYEADEDAVYDEEYTIDLSQLRPTVAFPHLPENTKTIDEITEPVAVDQAVIGSCTNGRIDDLRVAAQILKGRRVKKGLRCIVIPATQAIYLQAMEEGLLKIFIEAGAVVSTPTCGPCLGGYMGILAEGERCISTTNRNFVGRMGHVKSEVYLASPAVAAASAVTG |
Sequence similarities
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length422
- Mass (Da)45,244
- Last updated2023-05-03 v1
- ChecksumE373844BE68347C4