A0A9D1CNB6 · A0A9D1CNB6_9FIRM
- ProteinL-lactate dehydrogenase
- Geneldh
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids316 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of lactate to pyruvate.
Catalytic activity
- (S)-lactate + NAD+ = pyruvate + NADH + H+
Pathway
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 8-13 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 12 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 33 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 38 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 63 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 77-78 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 80 | substrate | |||
Binding site | 86 | substrate | |||
Binding site | 93 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 116-118 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 118 | substrate | |||
Binding site | 118-121 | substrate | |||
Binding site | 141 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 146-149 | substrate | |||
Binding site | 149 | substrate | |||
Active site | 173 | Proton acceptor | |||
Binding site | 234 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-lactate dehydrogenase activity | |
Biological Process | glycolytic process | |
Biological Process | lactate metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-lactate dehydrogenase
- EC number
- Short namesL-LDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Oscillospiraceae > Oscillospiraceae incertae sedis > Candidatus Avoscillospira
Accessions
- Primary accessionA0A9D1CNB6
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-140 | Lactate/malate dehydrogenase N-terminal | |||
Domain | 143-314 | Lactate/malate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the LDH/MDH superfamily. LDH family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length316
- Mass (Da)33,947
- Last updated2023-05-03 v1
- ChecksumCE385BDB1285F90C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DVFN01000035 EMBL· GenBank· DDBJ | HIQ69202.1 EMBL· GenBank· DDBJ | Genomic DNA |