A0A9D1A6U8 · A0A9D1A6U8_9FIRM

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site1Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site27substrate
Binding site53substrate
Site63-64Cleavage; by autolysis
Active site64Nucleophile
Binding site64substrate
Binding site150substrate
Binding site276substrate
Binding site281substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      IAA70_02875

Organism names

Accessions

  • Primary accession
    A0A9D1A6U8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50397670131-63Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_503976701264-281Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    29,112
  • Last updated
    2023-05-03 v1
  • Checksum
    D9AFE343F01D1D5A
TPIAAAMPELAAALGDHSREAAEAIMTTDTKVKEIAVAFSVGGKTCKLGGIAKGSGMIHPDLATMLVFLTTDCAIAPEMLQKALKADVSKTFNMVSVDGDTSTNDMVTILANGMAGNDPITAEGADFESFMAALNSVTLYLCRAIAGDGEGATKLLECKVTGAKTEAVAKTVAKSIICSSLTKAAMFGADANWGRVLCAIGYSGADVDVSQVDVSFASKKGEILVCQDGAGVDFSEETAKEILLEPEIDILVTLHEGAGSATAWGCDLTYDYVKINGDYRT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DVGD01000080
EMBL· GenBank· DDBJ
HIR09329.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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