A0A9C9PKR7 · A0A9C9PKR7_9GAMM

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site14-16N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site64(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site89-92(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site106(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site108Proton donor
Site144Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      ENF37_05960

Organism names

  • Taxonomic identifier
  • Organism
    Beggiatoa sp
  • Strain
    • HyVt-12
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Thiotrichaceae > Beggiatoa

Accessions

  • Primary accession
    A0A9C9PKR7

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-181Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    21,317
  • Last updated
    2023-05-03 v1
  • Checksum
    1D405D5F80646585
MAKLPLVALISGRGSNLKAIIDAADPLIEIRAVISNRPQAPGLLYAQQAGIATQIIDHKTFKSRLEFDTALQTAIDHYQPKLVILAGFMRILSPDFIKHYRGCLLNIHPSLLPAFKGLHTHQRVLQSNMKEHGTSVHFVTEELDSGPVIIQARVPVLPDDDEDSLAARVLQEEHRIYPQAIHWFAQGRLKT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQWX01000218
EMBL· GenBank· DDBJ
HEW98174.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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