A0A9C7PRP0 · A0A9C7PRP0_9RHOD

  • Protein
    Phosphatidylethanolamine N-methyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site138-140S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site220-221S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PEAMT
    ; PEMT
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • ORF names
      GpartN1_g293.t1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NBRC 102759
  • Taxonomic lineage
    Eukaryota > Rhodophyta > Bangiophyceae > Galdieriales > Galdieriaceae > Galdieria

Accessions

  • Primary accession
    A0A9C7PRP0

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, intramembrane, transmembrane.

TypeIDPosition(s)Description
Topological domain1-52Lumenal
Intramembrane53-73Helical
Transmembrane55-72Helical
Topological domain74-85Lumenal
Transmembrane78-106Helical
Topological domain107-133Cytoplasmic
Transmembrane127-149Helical
Topological domain155-197Lumenal
Transmembrane190-211Helical
Topological domain219-240Cytoplasmic

Keywords

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    240
  • Mass (Da)
    27,781
  • Last updated
    2023-05-03 v1
  • Checksum
    ECA5A3386C4647F7
MEMDLTVAKNNLKQVYHFIDAILSKRDYPLVQLLLHFFESLHLRSSVINFYDPKLARALIYTTLAPIIWNILARLEYFFHIISFLFFGKRMGCYVLALWILLFSLYRDLLVMEAIQVQPTLKYLEETHLVALAYILGALGGILVITSFLRLGITGTFLGDYFGIYLEEKVSGFPFSFCSNPMYDGSTLLFISKALLASSPAGLLLAFWVYVMYRIACTFEEPFTDYIYRYRATNQAKKKR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BQMJ01000002
EMBL· GenBank· DDBJ
GJQ08502.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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