A0A9C7B6Q3 · A0A9C7B6Q3_9THEO

  • Protein
    Thiamine-phosphate synthase
  • Gene
    thiE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37-414-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site694-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site89Mg2+ (UniProtKB | ChEBI)
Binding site1084-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site134-1362-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate (UniProtKB | ChEBI)
Binding site1374-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site1652-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate (UniProtKB | ChEBI)
Binding site185-1862-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionthiamine-phosphate diphosphorylase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine-phosphate synthase
  • EC number
  • Short names
    TP synthase
    ; TPS
  • Alternative names
    • Thiamine-phosphate pyrophosphorylase
      (TMP pyrophosphorylase
      ; TMP-PPase
      )

Gene names

    • Name
      thiE
    • ORF names
      kuro4_27140

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Kuro-4
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Thermoanaerobacterales > Thermoanaerobacteraceae > Gelria

Accessions

  • Primary accession
    A0A9C7B6Q3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-188Thiamine phosphate synthase/TenI

Sequence similarities

Belongs to the thiamine-phosphate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    21,773
  • Last updated
    2023-05-03 v1
  • Checksum
    E8224E13154C30D8
MQVNYELYAITDRRLAGGRSSAEVMEKAIRGGVTLVQLREKEAGGREMVAEAQTLLAVTRRYGVPLIVNDRLDVALAVDAEGVHLGQEDIPCRLARQILGPEKIIGVSASSVEEALQAEADGADYLGVGAVFPTGTKADAGEAIGLEPLKAIKAAVKIPVVAIGGINAANAAAVAATGVDGLAVVSAVVAAPDPQDAARRLVAAFRARPGKC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024619
EMBL· GenBank· DDBJ
BCV25941.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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