A0A9C7B299 · A0A9C7B299_9THEO

  • Protein
    Octanoyltransferase
  • Gene
    lipB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site75-82substrate
Site139Lowers pKa of active site Cys
Binding site142-144substrate
Binding site155-157substrate
Active site173Acyl-thioester intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlipoyl(octanoyl) transferase activity
Biological Processprotein lipoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Octanoyltransferase
  • EC number
  • Alternative names
    • Lipoate-protein ligase B
    • Lipoyl/octanoyl transferase
    • Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase

Gene names

    • Name
      lipB
    • ORF names
      kuro4_02390

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Kuro-4
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Thermoanaerobacterales > Thermoanaerobacteraceae > Gelria

Accessions

  • Primary accession
    A0A9C7B299

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-212BPL/LPL catalytic

Sequence similarities

Belongs to the LipB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    24,715
  • Last updated
    2023-05-03 v1
  • Checksum
    0A093C9266808A32
MHAKAVWLGRLEYGAALKQQKELVAKVRRGEEPDTLLLVEHDPVITLGRTAKREHLLFKEAALAEQGISVFAVERGGDVTYHGPGQLVGYPILNLNRHGRDLHLLLRNYEEVLIRALADFGVAGRRFPPYTGVWVGEEKVAAIGVAVEHWVSFHGFAFNVDPNLDHFGLIVPCGISQYGVTSLARLLGRPVELFEVIPHVVHHFADVFGLTLAPSAGRQPVGSEG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024619
EMBL· GenBank· DDBJ
BCV23466.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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