A0A9C7ATS3 · A0A9C7ATS3_9THEO

  • Protein
    Elongation factor 4
  • Gene
    lepA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site19-24GTP (UniProtKB | ChEBI)
Binding site136-139GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      kuro4_24280

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Kuro-4
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Thermoanaerobacterales > Thermoanaerobacteraceae > Gelria

Accessions

  • Primary accession
    A0A9C7ATS3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-189Tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    601
  • Mass (Da)
    66,589
  • Last updated
    2023-05-03 v1
  • Checksum
    7FC2CB0848B525E6
MPQERTAHIRNFSIIAHIDHGKSTLADRILELTGTLSAREMTDQVLDQMDLERERGITIKLQPVRISYRAQDGQEYELNLIDTPGHVDFTYEVSRSLAACEGALLVVDATQGIEAQTLANTYLALEHNLTIIPVINKIDLPSADPERVRRELADVLGLDPAEAILCSAKTGEGVPEVLEAVVARIPPPAGASDAPLAALIFDSKFDSYRGVIAYVRVMQGSIRRGQKIRLLATGKEYEVGEVGVFRPAFTPVDMLGPGEVGYLSAGIKIIQDARVGDTITAAARPVAKPLPGYRRLRPMVYCGIYPQETSDYDALREALEKLQLNDAALVFEPEKSVALGFGFRCGFLGLLHMEIVEERLEREFGVQLIATAPNVVYEVTKTDGEVLAVESPAKLPPPTEIASLAEPYVRATIIVPGDFVGAVMELAQEKRGTYHNMEYLDQTRVLLTYDLPLSEIIFDFFDLLKSRTRGYASLDYDYLGHRPSDLVKLDILINGEPVDALSLIVHRERAQAQGRRLVEKLRSLIPRQLFEVPIQAAVGGRVIARETVRALRKDVLAKCYGGDVTRKRKLLEKQKEGKRRMKQVGSVEIPQEAFMAVLKVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024619
EMBL· GenBank· DDBJ
BCV25655.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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