A0A991B922 · A0A991B922_MOUSE

  • Protein
    Myc proto-oncogene protein
  • Gene
    Myc
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular ComponentMyc-Max complex
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular ComponentRNA polymerase II transcription repressor complex
Molecular Functioncore promoter sequence-specific DNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor binding
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionE-box binding
Molecular Functionidentical protein binding
Molecular Functionprotein dimerization activity
Molecular FunctionSCF ubiquitin ligase complex binding
Molecular Functiontranscription coregulator binding
Molecular Functiontranscription regulator activator activity
Biological Processcellular response to hypoxia
Biological Processcellular response to UV
Biological Processcellular response to xenobiotic stimulus
Biological Processchromosome organization
Biological ProcessDNA damage response
Biological ProcessERK1 and ERK2 cascade
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processintracellular iron ion homeostasis
Biological Processnegative regulation of cell division
Biological Processnegative regulation of fibroblast proliferation
Biological Processnegative regulation of gene expression via chromosomal CpG island methylation
Biological Processnegative regulation of monocyte differentiation
Biological Processnegative regulation of transcription initiation by RNA polymerase II
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Biological Processpositive regulation of miRNA transcription
Biological Processprotein-DNA complex disassembly
Biological Processregulation of cell cycle process
Biological Processregulation of telomere maintenance
Biological Processresponse to gamma radiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myc proto-oncogene protein

Gene names

    • Name
      Myc

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A991B922

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Efficient DNA binding requires dimerization with another bHLH protein.

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain, coiled coil.

TypeIDPosition(s)Description
Compositional bias220-248Polar residues
Region220-380Disordered
Compositional bias360-380Basic and acidic residues
Domain369-421BHLH
Coiled coil382-452

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    50,660
  • Last updated
    2023-05-03 v1
  • Checksum
    39263D49D2D0ECA5
LDFLWALETPQTATTMPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSPARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLLSSESSPRASPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPSRGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSSPRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSIQADEHKLTSEKDLLRKRREQLKHKLEQLRNSGA

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P01108MYC_MOUSEMyc454
A0A991CU09A0A991CU09_MOUSEMyc453
E0CZD1E0CZD1_MOUSEMyc32

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias220-248Polar residues
Compositional bias360-380Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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