A0A977PTQ9 · A0A977PTQ9_9ACAR

Function

function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentsignal recognition particle, endoplasmic reticulum targeting
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular Functionendoplasmic reticulum signal peptide binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane, translocation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle 54 kDa protein

Gene names

    • Name
      Srp54k

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Sarcoptiformes > Oribatida > Brachypylina > Ameronothroidea > Fortuyniidae > Fortuynia

Accessions

  • Primary accession
    A0A977PTQ9

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain262-275SRP54-type proteins GTP-binding

Domain

The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    464
  • Mass (Da)
    51,115
  • Last updated
    2023-02-22 v1
  • Checksum
    9C4841EEF82EEF42
RKITSALRSLGNATIINKEVLDGLLKDICTALLEADVNIKLVKQLRENVRSVIDFDEMAAGLNKRRMIQMAVFKELVKLVDPGVKAWTPVKGRTNVVMFVGLQGSGKTTTCTKMAYYYVRKGWKCALVCADTFRAGAFDQLKQNATKARIPFYGSYTESDPVVIASEGVEKFTNEGFEVIVVDTSGRHKQESSLFEEMLAISTAVQPNLIIYVMDASIGQACEAQARAFKSKVDVGAVIVTKLDGHARGGGALSAVAATQSPISFIGTGEHMDDFEQFKVKPFVSKLLGMGDIEGLIDKVNELKLDDNEELIEKLKHGEFTLRDMYEQFTNIMKMGPFHQILNMIPGFGADLVKGASEAESMSRLKRLMTIMDSMSDSELDSREGAKLFTKQQTRIARVARGSGVTQKEVQDLLTQYTKFAAVVKKMGGIKGLFKGGDMAKNVNPTQMAKLNQQMAKMMDPRVL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue464

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OM471589
EMBL· GenBank· DDBJ
UXE52133.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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