A0A977PTH2 · A0A977PTH2_9ACAR

  • Protein
    Signal recognition particle 54 kDa protein
  • Gene
    Srp54k
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentsignal recognition particle, endoplasmic reticulum targeting
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular Functionendoplasmic reticulum signal peptide binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane, translocation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle 54 kDa protein

Gene names

    • Name
      Srp54k

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Trombidiformes > Prostigmata > Anystina > Parasitengona > Trombidioidea > Johnstonianidae > Johnstoniana

Accessions

  • Primary accession
    A0A977PTH2

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain262-275SRP54-type proteins GTP-binding

Domain

The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    470
  • Mass (Da)
    51,937
  • Last updated
    2023-02-22 v1
  • Checksum
    95C6C3ACA12568EA
RKITSALRSLGNATIINKEVLDGLLKEVCTALLEADVNIKLVKQLRENVRQVIDFEEMAAGLNKRRMIQMAVFKELVKLVDPGVKAWQPTKGRPNVVMFVGLQGSGKTTTCTKMAYYYLKKGWKCCLVCADTFRAGAFDQLKQNATKARIPFYGSYTESDPVVIASEGVDKFHKEGFEIIIVDTSGRHKQEKSLFEEMLSISNAIQPNLVIYVMDASIGQACEGQARAFKSKVDVGAVVVTKLDGHAKGGGALSAVAATQSPIIFIGTGEHVDDFEPFKVKPFVSKLLGMGDIEGLIDKVNELNIKENEELIEKLKHGEFTLRDMYEQFTNIMKMGPFNQILNMIPGFGAELAKGASEAESMARLKRLMTIMDSMSDAELDSREGAKLFTKQNTRIIRVSRGSGVTVREVQELLTQYTKFAAVVKKMGGIKGLFRGGDMSKNVNPSQMAKLNQQMAKMMDPRVLHHMGGM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue470

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OM471520
EMBL· GenBank· DDBJ
UXE52064.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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