A0A977K961 · A0A977K961_9CREN

Function

function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

Catalytic activity

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site112NAD+ (UniProtKB | ChEBI)
Binding site168NAD+ (UniProtKB | ChEBI)
Active site196

GO annotations

AspectTerm
Molecular Functionaspartate dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological ProcessNAD biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-aspartate dehydrogenase
  • EC number

Gene names

    • Name
      nadX
    • ORF names
      IPA_01770

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 13166
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Desulfurococcales > Desulfurococcaceae > Ignicoccus

Accessions

  • Primary accession
    A0A977K961

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-109Aspartate/homoserine dehydrogenase NAD-binding
Domain146-231Aspartate dehydrogenase

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    247
  • Mass (Da)
    27,067
  • Last updated
    2023-02-22 v1
  • Checksum
    006ECCD0996D91E7
MKICVIGCGNVARVLKEKLEEELVFYDRHPEKCKELCENCFFEDPIEMFESGCDLIVEAASPKAVEELGLEAVKRADLLVLSVGALINEELREKLIKVAEESGHKVYVPSGAIAGIDAIKALREVGIDEVRITVRKNPKSLGVETSEEKVLFEGSAEEAVKKFPFNVNVVATLKLASGAPVKVRVVADPKVDRNIHQIEVISKASNVFIRVENVPSPYNPKTSYLAILSVLRTIKEIAKGGVLRVGT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006868
EMBL· GenBank· DDBJ
UXD21246.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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